J
João Ruggiero
Researcher at Sao Paulo State University
Publications - 3
Citations - 44
João Ruggiero is an academic researcher from Sao Paulo State University. The author has contributed to research in topics: Intercalation (chemistry) & Sequence (medicine). The author has an hindex of 2, co-authored 3 publications receiving 44 citations. Previous affiliations of João Ruggiero include University of Trieste.
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On the interaction of daunomycin with synthetic alternating DNAs: Sequence specificity and polyelectrolyte effects on the intercalation equilibrium
TL;DR: The anticooperative nature of the interaction is essentially polyelectrolytic in origin, and the structural results obtained from the daunomycin‐d[(CGTACG)]2 crystal suggest that the 2‐NH2 group of guanine might be responsible for such a phenomenon.
Journal ArticleDOI
Charge effect in the interaction of doxorubicin and derivatives with polydeoxynucleotides
TL;DR: The equilibrium interaction of doxorubicin and its N-acetyl derivative with a series of purine-pyrimidine alternating polydeoxynucleotides has been studied through spectrofluorometry to assess the relevance of the electrostatic contribution to DNA intercalation.