Franco Quadrifoglio

TL;DR: The most relevant information concerning APE1's different functions are attempted to coalesce in order to shed new light and to focus current and future studies to fully understand this unique molecule that is acquiring more and more interest and translational relevance in the field of molecular medicine.

TL;DR: The data demonstrate that APE1 affects cell growth by directly acting on RNA quality control mechanisms, thus affecting gene expression through posttranscriptional mechanisms.

TL;DR: The physiological reduction in lactobacillus colonization of the vagina in postmenopausal women does not cause an increase in bacterial-vaginosis prevalence, and reversion of lactOBacillus flora to premenopausal levels due to HRT does not increase the prevalence of bacterial vaginosis in post menopausal women.

TL;DR: It is concluded that cytosine methylation expands the pH range compatible with triplex formation by one pH unit and indicates that the extra stability imparted to the triplex by methylcytosine is entropic in origin.

TL;DR: Investigation of the relationship between interleukin (IL)-8, IL-1beta and neutrophils in vaginal fluid obtained from 60 healthy women and 51 women who were bacterial vaginosis (BV) positive shows that BV causes a large increase inIL-1 beta concentrations which is not paralleled by an increase in IL-8 concentrations in vagina fluid, suggesting that Bv-associated factors more specifically dampenIL-8 rather than IL- 1beta.