Showing papers in "Biochimica et Biophysica Acta in 1992"

TL;DR: The structure-function relationship of PEG-derivatized phosphatidylethanolamine (PEG-PE) has been examined by measurement of blood lifetime and tissue distribution in both mice and rats and Steric stabilization has been proposed as a theoretical basis for the results.

TL;DR: The structure and function of LHC II, the light-harvesting chlorophyll a / b protein complex, and the regulation of phosphorylation, as well as its function in Photosystem II are studied.

TL;DR: The studies suggest this domain is the structural region responsible for the bacterial properties of lactoferrin, having effectiveness against various Gram-negative and Gram-positive bacteria at concentrations between 0.3 microM and 3.0 microM, depending on the target strain.

TL;DR: Osmotic gradient, for example, is sufficiently strong to push at least 0.5 mg of lipids per hour and cm2 through the skin permeability barrier in the region of stratum corneum, but does not contribute much to the lipid penetration into dermis.

TL;DR: Evidence is discussed for roles of cardiolipins in oxidative phosphorylation mechanisms that regulate State 4 respiration by returning ejected protons across and over bacterial and mitochondrial membrane phospholipids, and that regulates State 3 respiration through the relative contributions of proteins that transport protons, electrons and/or metabolites.

TL;DR: A novel and rapid multiparameter flow cytometric assay which discriminates and quantifies viable, apoptotic and necrotic cells via measurement of forward and side light scatter (proportional to cell diameter and internal granularity, respectively) and the DNA-binding fluorophores Hoechst 33342 and propidium is described.

TL;DR: The lateral diffusion experiments confirm that continuous extended bilayers are formed by the monolayer-fusion technique, independent of the method by which the bilayers were prepared.

TL;DR: The results of the analysis of hotspots of mutations support the idea that emergence of somatic mutation is significantly influenced by neighbouring base sequences and is supposed that this influence is an important feature of somatics hypermutagenesis.

TL;DR: Results indicate that only spleen homing liposomes can be used as a blocking reagent to prolong the circulation time of the large GM1-containing liposome circulation time in the blood.

TL;DR: The physical proper and physical proper behavior of PE and PE l i r~somes are studied, as well as the Divalent cation effect, which describes theivalent effect of pH in PE systems.

TL;DR: Study of GSK-3 had an inauspicious beginning rooted in intermediary metabolism, however, owing to the fortuitous convergence of several disparate areas of biology, the enzyme now offers unique opportunities for study of the control of a variety cellular processes.

TL;DR: It is concluded that the repulsive barrier properties of lipid-grafted PEG polymer chains originate mainly from a steric pressure and that this simple polymer steric stabilization is the basis for the extended in vivo circulation times observed for polymer- grafted liposomes.

TL;DR: Results clearly show that tea catechins, in particular their gallate esters, effectively reduce cholesterol absorption from the intestine by reducing solubility of cholesterol in mixed micelles.

TL;DR: Prolonged circulation with PEG-PE is independent of cholesterol, degree of saturation in either the PC or the PE lipid anchor, lipid dose, or addition of other negatively charged lipids, phosphatidylglycerol or cholesterol sulfate.

TL;DR: The reproducibility of the results makes it likely that analysis of fatty-acid composition of plasma lipids from individuals will prove useful in estimating the diet-related tendency for severe thrombotic, arthritic or other disorders that are mediated by (n - 6) eicosanoids.

TL;DR: Oral supplementation with CoQ increases CoQH2 in the plasma and all lipoproteins thereby increasing the resistance of LDL to radical oxidation and preventing the formation of lipid hydroperoxides.

TL;DR: The rate of esterification catalysed by an immobilised lipase suspended in an organic reaction mixture shows similar dependence on aw in reaction mixtures based on five different organic solvents ranging in polarity from pentan-3-one to hexane, and in a liquid reactant mixture.

TL;DR: An age-related increase in glycation and AGEs in both tissues is shown and a decrease in the interfibrillar spacing of corneal collagen with increasing age is demonstrated which may be related to changes in the proteoglycan composition of the interfibillar matrix.

TL;DR: Different mechanisms of liposome uptake by these two cell lines are suggested from the different patterns of uptake and the competition with various poly-anions.

TL;DR: The effect of negative surface charge and hydrophilic groups on liposome clearance from blood was investigated in mice usingliposome-entrapped 67gallium-deferoxamine as a label to find the need for negative charge in addition to the carbohydrate group for optimal effect on retardation of clearance is indicated.

TL;DR: Four different cationic derivatives of cholesterol were synthesized which contain either a tertiary or a quaternary amino head group, with and without a succinyl spacer-arm, and several adherent cell lines could be efficiently transfected with this liposome reagent without any apparent cytotoxicity.

TL;DR: This review summarizes the information available on the structure, function, biosynthesis, gene organization and pathobiochemistry of the known sphingolipid activator proteins and offers models for their mode of action and for the topology of lysosomal digestion of glycolipids.