J
Joe E. Tym
Researcher at Institute of Cancer Research
Publications - 4
Citations - 243
Joe E. Tym is an academic researcher from Institute of Cancer Research. The author has contributed to research in topics: Interaction network & Drug discovery. The author has an hindex of 3, co-authored 4 publications receiving 194 citations.
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Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines
James Campbell,Colm J. Ryan,Rachel Brough,Ilirjana Bajrami,Helen Pemberton,Irene Chong,Sara Costa-Cabral,Jessica Frankum,Aditi Gulati,Harriet Holme,Rowan Miller,Rowan Miller,Sophie Postel-Vinay,Rumana Rafiq,Wenbin Wei,Chris T. Williamson,David A. Quigley,Joe E. Tym,Bissan Al-Lazikani,Tim R. Fenton,Rachael Natrajan,Sandra J. Strauss,Alan Ashworth,Christopher J. Lord +23 more
TL;DR: The utility of siRNA screens to predict the drug sensitivity of genetically or histologically defined subsets of tumor cell lines, including an increased sensitivity of osteosarcoma cell lines to FGFR inhibitors and SMAD4 mutant tumor cells to mitotic inhibitors is demonstrated.
Journal ArticleDOI
canSAR: an integrated cancer public translational research and drug discovery resource.
TL;DR: CanSAR can, in a single place, rapidly identify biological annotation of a target, its structural characterization, expression levels and protein interaction data, as well as suitable cell lines for experiments, potential tool compounds and similarity to known drug targets.
Journal ArticleDOI
Objective, Quantitative, Data-Driven Assessment of Chemical Probes
TL;DR: The Probe Miner: Chemical Probes Objective Assessment resource is described, capitalizing on the plethora of public medicinal chemistry data to empower quantitative, objective, data-driven evaluation of chemical probes.
Posted ContentDOI
Objective, Quantitative, Data-Driven Assessment of Chemical Probes
TL;DR: The Probe Miner is described the Probe Miner: Chemical Probes Objective Assessment resource – capitalising on the plethora of public medicinal chemistry data to empower quantitative, objective, Big Data-driven assessment of chemical probes.