T
Tim R. Fenton
Researcher at University of Kent
Publications - 70
Citations - 5724
Tim R. Fenton is an academic researcher from University of Kent. The author has contributed to research in topics: Cancer & Phosphorylation. The author has an hindex of 29, co-authored 61 publications receiving 4815 citations. Previous affiliations of Tim R. Fenton include Ludwig Institute for Cancer Research & University of California, San Diego.
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Journal ArticleDOI
Malignant astrocytic glioma: genetics, biology, and paths to treatment.
Frank B. Furnari,Tim R. Fenton,Robert M. Bachoo,Akitake Mukasa,Jayne M. Stommel,Alexander H. Stegh,William C. Hahn,Keith L. Ligon,David N. Louis,Cameron Brennan,Lynda Chin,Ronald A. DePinho,Webster K. Cavenee +12 more
TL;DR: The recent confluence of advances in stem cell biology, cell signaling, genome and computational science and genetic model systems have revolutionized understanding of the mechanisms underlying the genetics, biology and clinical behavior of glioblastoma.
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Functions and regulation of the 70kDa ribosomal S6 kinases.
TL;DR: The current literature on the role of S6Ks in the regulation of cell growth, survival and proliferation downstream of various signalling pathways and how their dysregulation contributes to the pathogenesis of human diseases is reviewed.
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APOBEC-mediated cytosine deamination links PIK3CA helical domain mutations to human papillomavirus-driven tumor development
TL;DR: The findings implicate APOBEC activity as a key driver of PIK3CA mutagenesis and HPV-induced transformation and suggest that reduced exposure to exogenous carcinogens in HPV+ HNSCC creates a selective pressure that favors emergence of tumors with APOBec-mediated driver mutations.
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Targeted next-generation sequencing of head and neck squamous cell carcinoma identifies novel genetic alterations in HPV+ and HPV- tumors.
Matthias Lechner,Garrett M. Frampton,Tim R. Fenton,Andrew Feber,Gary A. Palmer,Amrita Jay,Nischalan Pillay,Martin Forster,Maureen T. Cronin,Doron Lipson,Vincent A. Miller,Tim Brennan,Stephen Henderson,Francis Vaz,Paul O'Flynn,Nicholas Kalavrezos,Roman Yelensky,Stephan Beck,Philip J. Stephens,Chris Boshoff +19 more
TL;DR: Findings strongly support a causal role for HPV, acting via p53 and RB pathway inhibition, in the pathogenesis of a subset of oropharyngeal cancers and suggest that studies of CDK inhibitors in HPV- disease may be warranted.
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Pan-cancer deconvolution of tumour composition using DNA methylation.
Ankur Chakravarthy,Ankur Chakravarthy,Andrew Furness,Kroopa Joshi,Ehsan Ghorani,Kirsty Ford,Matthew J. Ward,Emma King,Matt Lechner,Teresa Marafioti,Sergio A. Quezada,Gareth J. Thomas,Andrew Feber,Tim R. Fenton +13 more
TL;DR: The integrated analysis of tumour composition and genomics across a wide spectrum of solid cancers is reported, finding that treatment-naive hot tumours are markedly enriched for known immune-resistance genomic alterations, potentially explaining the heterogeneity of immunotherapy response and prognosis seen within this group.