J
Joel E. Schlosburg
Researcher at Scripps Research Institute
Publications - 48
Citations - 4826
Joel E. Schlosburg is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Cannabinoid receptor & Endocannabinoid system. The author has an hindex of 33, co-authored 47 publications receiving 4192 citations. Previous affiliations of Joel E. Schlosburg include VCU Medical Center & Virginia Commonwealth University.
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Journal ArticleDOI
Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects
Jonathan Z. Long,Weiwei Li,Lamont Booker,James J. Burston,Steven G. Kinsey,Joel E. Schlosburg,Franciso J Pavón,Antonia Serrano,Dana E. Selley,Loren H. Parsons,Aron H. Lichtman,Benjamin F. Cravatt +11 more
TL;DR: 2-AG endogenously modulates several behavioral processes classically associated with the pharmacology of cannabinoids and point to overlapping and unique functions for 2-AG and anandamide in vivo, indicating a functional segregation of endocannabinoid signaling pathways in vivo.
Journal ArticleDOI
Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system
Joel E. Schlosburg,Jacqueline L. Blankman,Jonathan Z. Long,Daniel K. Nomura,Bin Pan,Steven G. Kinsey,Peter T. Nguyen,Divya Ramesh,Lamont Booker,James J. Burston,Elizabeth A. Thomas,Dana E. Selley,Laura J. Sim-Selley,Qing-song Liu,Aron H. Lichtman,Benjamin F. Cravatt +15 more
TL;DR: Individual endocannabinoids generate distinct analgesic profiles that are either sustained or transitory and associated with agonism and functional antagonism of the brain cannabinoid system, respectively.
Journal ArticleDOI
Addiction as a Stress Surfeit Disorder
George F. Koob,Cara L. Buck,Ami Cohen,Scott Edwards,Paula E. Park,Joel E. Schlosburg,Brooke E. Schmeichel,Leandro F. Vendruscolo,Carrie L. Wade,Timothy W. Whitfield,Olivier George +10 more
TL;DR: Brain stress response systems are hypothesized to be activated by acute excessive drug intake, to be sensitized during repeated withdrawal, to persist into protracted abstinence, and to contribute to the development and persistence of addiction.
Journal ArticleDOI
Corticosteroid-Dependent Plasticity Mediates Compulsive Alcohol Drinking in Rats
Leandro F. Vendruscolo,Estelle Barbier,Joel E. Schlosburg,Kaushik K. Misra,Timothy W. Whitfield,Marian L. Logrip,Catherine Rivier,Vez Repunte-Canonigo,Eric P. Zorrilla,Pietro Paolo Sanna,Markus Heilig,George F. Koob +11 more
TL;DR: The GR system appears to be involved in the development of alcohol dependence and may represent a potential pharmacological target for the treatment of alcoholism.
Journal ArticleDOI
Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals
Leandro F. Vendruscolo,David Estey,Vivian Goodell,Lauren G. Macshane,Marian L. Logrip,Joel E. Schlosburg,M. Adrienne McGinn,Eva R. Zamora-Martinez,Joseph K. Belanoff,Hazel Hunt,Pietro Paolo Sanna,Olivier George,George F. Koob,Scott Edwards,Barbara J. Mason +14 more
TL;DR: It is demonstrated that the glucocorticoid receptor (GR) antagonist mifepristone reduces alcohol intake in alcohol-dependent rats but not in nondependent animals, and both systemic delivery and direct administration into the central nucleus of the amygdala, a critical stress-related brain region, were sufficient to reduce alcohol consumption in dependent animals.