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Weiwei Li
Researcher at Scripps Research Institute
Publications - 17
Citations - 2079
Weiwei Li is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Serine hydrolase & Cannabinoid receptor. The author has an hindex of 13, co-authored 14 publications receiving 1886 citations. Previous affiliations of Weiwei Li include National University of Singapore & Stanford University.
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Journal ArticleDOI
Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects
Jonathan Z. Long,Weiwei Li,Lamont Booker,James J. Burston,Steven G. Kinsey,Joel E. Schlosburg,Franciso J Pavón,Antonia Serrano,Dana E. Selley,Loren H. Parsons,Aron H. Lichtman,Benjamin F. Cravatt +11 more
TL;DR: 2-AG endogenously modulates several behavioral processes classically associated with the pharmacology of cannabinoids and point to overlapping and unique functions for 2-AG and anandamide in vivo, indicating a functional segregation of endocannabinoid signaling pathways in vivo.
Journal ArticleDOI
The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors
William R. Marrs,Jacqueline L. Blankman,Eric A. Horne,Aurore Thomazeau,Yi Hsing Lin,Jonathan Coy,Ágnes L. Bodor,Giulio G. Muccioli,Sherry Shu Jung Hu,Grace Woodruff,Susan Fung,Mathieu Lafourcade,Jessica P. Alexander,Jonathan Z. Long,Weiwei Li,Cong Xu,Thomas Möller,Ken Mackie,Olivier J. Manzoni,Benjamin F. Cravatt,Nephi Stella +20 more
TL;DR: The results indicate that ABHD6 is a rate-limiting step of 2-AG signaling and is therefore a bona fide member of the endocannabinoid signaling system.
Journal ArticleDOI
Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening
Daniel A. Bachovchin,Tianyang Ji,Weiwei Li,Gabriel M. Simon,Jacqueline L. Blankman,Alexander Adibekian,Heather Hoover,Sherry Niessen,Benjamin F. Cravatt +8 more
TL;DR: It is shown here that the vast majority of mammalian metabolic SHs can be labeled in proteomes by a single, active site-directed fluorophosphonate probe, and it is shown that lead carbamate inhibitors can be optimized into pharmacological probes that inactivate individual SHs with high specificity in vivo.
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A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases
TL;DR: A functional proteomic strategy to systematically develop potent and selective inhibitors for uncharacterized serine hydrolases and its application to the brain-enriched enzyme α/β-hydrolase-6 is described.
Journal ArticleDOI
Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes
Eduardo Domínguez,Andrea Galmozzi,Jae Won Chang,Ku-Lung Hsu,Joanna Pawlak,Weiwei Li,C. Godio,Jason R. Thomas,David Partida,Sherry Niessen,Paul E. O'Brien,Aaron P. Russell,Matthew J. Watt,Daniel K. Nomura,Benjamin F. Cravatt,Enrique Saez +15 more
TL;DR: Treatment of two mouse models of obesity-diabetes with a Ces3 inhibitor ameliorates multiple features of metabolic syndrome, illustrating the power of the described strategy to accelerate the identification and pharmacologic validation of new therapeutic targets.