Joel Katz

TL;DR: This review examines the clinical and experimental evidence which points to a contribution of central Neurol plasticity to the development of pathological pain, and assesses the physiological, biochemical, cellular and molecular mechanisms that underlie plasticity induced in the central nervous system in response to noxious peripheral stimulation.

TL;DR: Circum circumcised infants showed a stronger pain response to subsequent routine vaccination than uncircumcised infants, and preoperative treatment with Emla attenuated the painresponse to vaccination.

TL;DR: Aggressive management of early postoperative pain may reduce the likelihood of long-term post-thoracotomyPain intensity 24 h after surgery, at rest, and after movement was significantly greater among patients who developed long- term pain compared with pain-free patients.

TL;DR: For instance, this paper argued that pain is not simply the end product of a linear sensory transmission system; rather, it is a dynamic process that involves continuous interactions among complex ascending and descending systems that actively participate in the selection, abstraction, and synthesis of information from the total sensory input.

TL;DR: It is argued that a focus on the transition from acute to chronic pain may reveal important cues that will help to predict who will go on to develop chronic pain and who will not and how to identify the risk factors and protective factors that predict the course of recovery.