J
Joel M. Reid
Researcher at Mayo Clinic
Publications - 274
Citations - 11448
Joel M. Reid is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Pharmacokinetics & Medicine. The author has an hindex of 50, co-authored 248 publications receiving 10094 citations. Previous affiliations of Joel M. Reid include Oregon Health & Science University & Upjohn.
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Journal ArticleDOI
A phase I dose escalation study of irinotecan (CPT-11), oxaliplatin (Oxal), and capecitabine (Cap) within three UGT1A1 TA promoter cohorts (6/6, 6/7, and 7/7)
Matthew P. Goetz,Stephanie L. Safgren,Richard M. Goldberg,Axel Grothey,Sumithra J. Mandrekar,Joel M. Reid,Charles Erlichman,Araba A. Adjei,Joseph Rubin,Matthew M. Ames +9 more
TL;DR: A phase I study to develop UGT1A1 genotype specific dosing of CPT-11, Oxal, and Cap in pts with advanced solid tumors with higher risk of C PT-11 induced diarrhea and neutropenia.
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Phase I trial of ontuxizumab (MORAb-004) in children with relapsed or refractory solid tumors: A Children’s Oncology Group Study.
Robin E. Norris,Elizabeth Fox,Joel M. Reid,Andrew T. Ralya,Xiaowei Liu,Charlotte H. Ahern,Charles G. Minard,Jodell Dahl,Rachel Eubank,Brenda J. Weigel +9 more
TL;DR: Ontuxizumab binding to endosialin may interfere with platelet-derived growth factor (PDGF) signaling and prevention of protein interactions involved in tumor-stroma organization and new vessel formation.
Journal ArticleDOI
Phase I trial of OSI-774 and CPT-11 in patients with advanced solid tumors
Ravi D. Rao,Joel M. Reid,Matthew P. Goetz,Alfred Furth,Sumithra J. Mandrekar,Araba A. Adjei,Matthew M. Ames,Stephanie L. Safgren,Charles Erlichman,Henry C. Pitot +9 more
TL;DR: The MTD of this combination of OSI-774 and CPT-11 in patients with advanced solid tumors has not yet been determined and the DLTs appear related to presence of UGT1A1 polymorphisms.
Journal ArticleDOI
Reductive amination of α-Ketoglutarate in metabolite extracts results in glutamate overestimation
Elizabeth K. Wiese,Sadae Hitosugi,Sarah A. Buhrow,Sharon T. Loa,Annapoorna Sreedhar,Joel M. Reid,Wilson I. Gonsalves,Taro Hitosugi +7 more
TL;DR: It is shown that α-ketoglutarate is reductively aminated to glutamate in methanol:water metabolite extracts, which introduces an artifact into metabolomics studies, and glutamate levels have been overestimated by 10-50% due to α-KG reductive amination.
Journal ArticleDOI
Limited Sampling Models for Irinotecan Pharmacokinetics
Jeff A. Sloan,Jeff A. Sloan,P. Atherton Skaff,P. Atherton Skaff,Joel M. Reid,Joel M. Reid,Henry C. Pitot,Henry C. Pitot,Charles Erlichman,Charles Erlichman,L. Schaaf,L. Schaaf +11 more
TL;DR: It is necessary to select patients suitable for vaginal or laparoscopic mesh placement for intranasal administration based on prior history and once they provide informed consent for surgery.