S
Sharon T. Loa
Researcher at Mayo Clinic
Publications - 3
Citations - 18
Sharon T. Loa is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Glutaminolysis & PKM2. The author has an hindex of 1, co-authored 2 publications receiving 3 citations.
Papers
More filters
Journal ArticleDOI
Enzymatic activation of pyruvate kinase increases cytosolic oxaloacetate to inhibit the Warburg effect.
Elizabeth K. Wiese,Sadae Hitosugi,Sharon T. Loa,Annapoorna Sreedhar,Lindsey G. Andres-Beck,Kiran Kurmi,Kiran Kurmi,Yuan-Ping Pang,Larry M. Karnitz,Wilson I. Gonsalves,Taro Hitosugi +10 more
TL;DR: Wiese et al. as mentioned in this paper showed that oxaloacetate (OAA) is a competitive inhibitor of human lactate dehydrogenase A (LDHA) and that elevated PKM2 activity increases de novo synthesis of OAA through glutaminolysis, thereby inhibiting LDHA in cancer cells.
Journal ArticleDOI
Reductive amination of α-Ketoglutarate in metabolite extracts results in glutamate overestimation
Elizabeth K. Wiese,Sadae Hitosugi,Sarah A. Buhrow,Sharon T. Loa,Annapoorna Sreedhar,Joel M. Reid,Wilson I. Gonsalves,Taro Hitosugi +7 more
TL;DR: It is shown that α-ketoglutarate is reductively aminated to glutamate in methanol:water metabolite extracts, which introduces an artifact into metabolomics studies, and glutamate levels have been overestimated by 10-50% due to α-KG reductive amination.
Journal ArticleDOI
Succinate based polymers drive immunometabolism in dendritic cells to generate cancer immunotherapy.
Sahil Inamdar,J. L. Mangal,Nathan Ng,Hoda Shokrollahzadeh Behbahani,Thomas E Rubino,Xiaojian Shi,Sharon T. Loa,Jordan R. Yaron,Taro Hitosugi,Haiwei Gu,Marion Curtis,Abhinav P. Acharya +11 more
TL;DR: In this paper , the authors used biomaterials for the controlled delivery of succinate metabolite to phagocytic immune cells, which activated them and modulated their metabolism in the presence of metabolic inhibitors.