J
Joel Njah
Researcher at University of Pittsburgh
Publications - 3
Citations - 693
Joel Njah is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Mesenchymal stem cell & Macrophage. The author has an hindex of 2, co-authored 3 publications receiving 515 citations.
Papers
More filters
Journal ArticleDOI
Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs
Donald G. Phinney,Michelangelo Di Giuseppe,Joel Njah,Ernest Sala,Sruti Shiva,Claudette M. St. Croix,Donna B. Stolz,Simon C. Watkins,Y. Peter Di,George D. Leikauf,Jay K. Kolls,David W. H. Riches,Giuseppe DeIuliis,Naftali Kaminski,Siddaraju V. Boregowda,David H. McKenna,Luis A. Ortiz +16 more
TL;DR: It is shown that MSCs manage intracellular oxidative stress by targeting depolarized mitochondria to the plasma membrane via arrestin domain-containing protein 1-mediated microvesicles and simultaneously shed micro RNA-containing exosomes that inhibit macrophage activation by suppressing Toll-like receptor signalling.
Journal ArticleDOI
TNFR1/Phox Interaction and TNFR1 Mitochondrial Translocation Thwart Silica-Induced Pulmonary Fibrosis
Fabrizio Fazzi,Joel Njah,Michelangelo Di Giuseppe,Daniel E. Winnica,Kristina Go,Ernest Sala,Claudette M. St. Croix,Simon C. Watkins,Vladimir A. Tyurin,Donald G. Phinney,Cheryl L. Fattman,George D. Leikauf,Valerian E. Kagan,Luis A. Ortiz +13 more
TL;DR: It is demonstrated that reduced p47phox expression in IC21 macrophages is linked to enhanced mtROS generation, cardiolipin oxidation, and accumulation of cardiolaipin hydrolysis products, culminating in cell death.