C
Claudette M. St. Croix
Researcher at University of Pittsburgh
Publications - 156
Citations - 9781
Claudette M. St. Croix is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Oxidative stress & Medicine. The author has an hindex of 43, co-authored 140 publications receiving 7107 citations. Previous affiliations of Claudette M. St. Croix include University of Wisconsin-Madison.
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Journal ArticleDOI
Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis
Valerian E. Kagan,Gaowei Mao,Feng Qu,José Pedro Friedmann Angeli,Sebastian Doll,Claudette M. St. Croix,Haider H. Dar,Bing Liu,Vladimir A. Tyurin,Vladimir B. Ritov,Alexandr A. Kapralov,Andrew A. Amoscato,Jianfei Jiang,Tamil S. Anthonymuthu,Dariush Mohammadyani,Qin Yang,Bettina Proneth,Judith Klein-Seetharaman,Simon C. Watkins,Ivet Bahar,Joel S. Greenberger,Rama K. Mallampalli,Brent R. Stockwell,Yulia Y. Tyurina,Marcus Conrad,Hülya Bayır +25 more
TL;DR: It is discovered that ferroptosis involves a highly organized oxygenation center, wherein oxidation in endoplasmic-reticulum-associated compartments occurs on only one class of phospholipids (phosphatidylethanolamines (PEs) and is specific toward two fatty acyls-arachidonoyl (AA) and AdA (AdA).
Journal ArticleDOI
Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs
Donald G. Phinney,Michelangelo Di Giuseppe,Joel Njah,Ernest Sala,Sruti Shiva,Claudette M. St. Croix,Donna B. Stolz,Simon C. Watkins,Y. Peter Di,George D. Leikauf,Jay K. Kolls,David W. H. Riches,Giuseppe DeIuliis,Naftali Kaminski,Siddaraju V. Boregowda,David H. McKenna,Luis A. Ortiz +16 more
TL;DR: It is shown that MSCs manage intracellular oxidative stress by targeting depolarized mitochondria to the plasma membrane via arrestin domain-containing protein 1-mediated microvesicles and simultaneously shed micro RNA-containing exosomes that inhibit macrophage activation by suppressing Toll-like receptor signalling.
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PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals
Sally E. Wenzel,Yulia Y. Tyurina,Jinming Zhao,Claudette M. St. Croix,Haider H. Dar,Gaowei Mao,Vladimir A. Tyurin,Tamil S. Anthonymuthu,Alexandr A. Kapralov,Andrew A. Amoscato,Karolina Mikulska-Ruminska,Karolina Mikulska-Ruminska,Indira H. Shrivastava,Elizabeth M. Kenny,Qin Yang,Joel C. Rosenbaum,Louis J. Sparvero,David R. Emlet,Xiaoyan Wen,Yoshinori Minami,Feng Qu,Simon C. Watkins,Theodore R. Holman,Andrew P. VanDemark,John A. Kellum,Ivet Bahar,Hülya Bayır,Hülya Bayır,Valerian E. Kagan +28 more
TL;DR: It is discovered that PEBP1, a scaffold protein inhibitor of protein kinase cascades, complexes with two 15LO isoforms, 15LO1 and 15LO2, and changes their substrate competence to generate hydroperoxy-PE, a new target for drug discovery.
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PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis
Marta Bueno,Yen-Chun Lai,Yair Romero,Judith Brands,Claudette M. St. Croix,Christelle Kamga,Catherine Corey,Jose D. Herazo-Maya,John Sembrat,Janet S. Lee,Steve R. Duncan,Mauricio Rojas,Sruti Shiva,Charleen T. Chu,Ana L. Mora +14 more
TL;DR: The data indicate that PINK1 deficiency results in swollen, dysfunctional mitochondria and defective mitophagy, and promotes fibrosis in the aging lung, as well as in normal mice with advancing age.
Journal ArticleDOI
Effects of respiratory muscle work on exercise performance
Craig A. Harms,Craig A. Harms,Thomas J. Wetter,Claudette M. St. Croix,David F. Pegelow,Jerome A. Dempsey +5 more
TL;DR: It is speculated that this effect of the normal respiratory muscle load on performance in trained male cyclists is due to the associated reduction in leg blood flow, which enhances both the onset of leg fatigue and the intensity with which both leg and respiratory muscle efforts are perceived.