J
Joel Rosenbloom
Researcher at Thomas Jefferson University
Publications - 189
Citations - 10685
Joel Rosenbloom is an academic researcher from Thomas Jefferson University. The author has contributed to research in topics: Elastin & Tropoelastin. The author has an hindex of 58, co-authored 186 publications receiving 10231 citations. Previous affiliations of Joel Rosenbloom include Osaka University & Washington University in St. Louis.
Papers
More filters
Journal ArticleDOI
Extracellular matrix 4: the elastic fiber.
TL;DR: Analysis of the elastin gene has demonstrated that hydrophobic and cross‐linking domains are encoded in separate exons and that there is significant alternative splicing, resulting in multiple isoforms of tropoelastin.
Journal ArticleDOI
Transforming growth factor beta (TGF beta) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblasts.
TL;DR: The results indicate that TGF beta causes a marked enhancement of the production of types I and III collagens and fibronectin by cultured normal human dermal fibroblasts and may contribute to the development of pathological states of fibrosis.
Journal ArticleDOI
Alternative splicing of human elastin mRNA indicated by sequence analysis of cloned genomic and complementary DNA
Zena K. Indik,Helena Yeh,Norma Ornstein-Goldstein,Paul Sheppard,Noel Anderson,J. Rosenbloom,Leena Peltonen,Joel Rosenbloom +7 more
TL;DR: The results suggest the potential for significant variation in the precise molecular structure of the elastic fiber in the human population and suggest substantial alternative splicing of the mRNA.
Journal ArticleDOI
Cytokine Networks in the Regulation of Inflammation and Fibrosis in the Lung
TL;DR: These studies demonstrated the existence of complex cytokine networks by which inflammatory cells regulate fibroblast function and fibroblasts, in turn, feed back to regulate inflammatory cell function.
Journal ArticleDOI
RTX Toxins Recognize a β2 Integrin on the Surface of Human Target Cells
Edward T. Lally,Irene R. Kieba,Atsushi Sato,Cecelia L. Green,Joel Rosenbloom,Jon Korostoff,Jian Fei Wang,Bruce J. Shenker,Susan Ortlepp,Martyn K. Robinson,Paul C. Billings +10 more
TL;DR: A monoclonal antibody is obtained to a cell surface molecule present on toxin-sensitive HL60 cells that can inhibit cytolysis by both RTX toxins.