J
Joerg Huwyler
Researcher at Hoffmann-La Roche
Publications - 18
Citations - 381
Joerg Huwyler is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Alkyl & Metabotropic glutamate receptor 2. The author has an hindex of 5, co-authored 18 publications receiving 362 citations.
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Journal Article
Evidence that nicotinic alpha(7) receptors are not involved in the hyperlocomotor and rewarding effects of nicotine.
A.J. Grottick,Gerhard Trube,William A. Corrigall,Joerg Huwyler,Parichehr Malherbe,Wyler Rene,Guy A. Higgins +6 more
TL;DR: Results indicate a negligible role of alpha(7) receptors in nicotine-induced hyperlocomotion and reward in the rat, and support the view for an involvement of a member from the high-affinity nicotinic receptor subclass, possibly alpha(4)beta(2).
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9H-Xanthene-9-carboxylic acid [1,2,4]oxadiazol-3-yl- and (2H-tetrazol-5-yl)-amides as potent, orally available mGlu1 receptor enhancers.
TL;DR: The synthesis and the structure-activity relationship of this new class of positive allosteric modulators of mGlu1 receptors will be discussed in detail.
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Discovery of carmegliptin: a potent and long-acting dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Patrizio Mattei,Markus Boehringer,Patrick Di Giorgio,Holger Fischer,Michael Hennig,Joerg Huwyler,Buelent Kocer,Bernd Kuhn,Bernd Michael Loeffler,Alexander Macdonald,Robert Narquizian,Etienne Rauber,Elena Sebokova,Urs Sprecher +13 more
TL;DR: Design, synthesis, and SAR are described for a class of DPP-IV inhibitors based on aminobenzo[a]quinolizines with non-aromatic substituents in the S1 specificity pocket and one representative, carmegliptin (8p), was chosen for clinical development.
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Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 4. In vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists.
Thomas Johannes Woltering,Juergen Wichmann,Erwin Goetschi,Frédéric Knoflach,Theresa M. Ballard,Joerg Huwyler,Silvia Gatti +6 more
TL;DR: Combination studies with a cholinesterase inhibitor show apparent synergistic effects on working memory impairment induced by scopolamine in the delayed match to position task.
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Aryl- and heteroaryl-substituted aminobenzo[a]quinolizines as dipeptidyl peptidase IV inhibitors.
Markus Boehringer,Holger Fischer,Michael Hennig,Daniel Hunziker,Joerg Huwyler,Bernd Kuhn,Bernd Michael Loeffler,Thomas Luebbers,Patrizio Mattei,Robert Narquizian,Elena Sebokova,Urs Sprecher,Hans Peter Wessel +12 more
TL;DR: Synthesis and SAR are described for a structurally distinct class of DPP-IV inhibitors based on aminobenzo[a]quinolizines bearing (hetero-)aromatic substituents in the S1 specificity pocket that displays excellent in vivo activity and superior drug-like properties.