S
Silvia Gatti
Researcher at Hoffmann-La Roche
Publications - 37
Citations - 2765
Silvia Gatti is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Metabotropic glutamate receptor & Metabotropic glutamate receptor 2. The author has an hindex of 22, co-authored 37 publications receiving 2508 citations. Previous affiliations of Silvia Gatti include Mario Negri Institute for Pharmacological Research.
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Journal ArticleDOI
Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease
TL;DR: It is proposed that brain disorders and abnormal sleep have a common mechanistic origin and that many co-morbid pathologies that are found in brain disease arise from a destabilization of sleep mechanisms.
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Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity.
Porter Richard Hugh Phillip,Georg Jaeschke,Will Spooren,Theresa M. Ballard,Bernd Büttelmann,Sabine Kolczewski,Jens-Uwe Peters,Eric Prinssen,Jürgen Wichmann,Eric Vieira,Andreas Mühlemann,Silvia Gatti,Vincent Mutel,Pari Malherbe +13 more
TL;DR: The non-GABAergic activity of fenobam, coupled with its robust anxiolytic activity and reported efficacy in human in a double blind placebo-controlled trial, supports the potential of developing mGlu5 receptor antagonists with an improved therapeutic window over benzodiazepines as novel anxIOlytic agents.
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N-acetylcysteine and glutathione as inhibitors of tumor necrosis factor production.
Platon Peristeris,Burton D. Clark,Silvia Gatti,Raffaella Faggioni,Alberto Mantovani,Manuela Mengozzi,Scott F. Orencole,Marina Sironi,Pietro Ghezzi +8 more
TL;DR: The results indicated that oral administration of NAC protects against LPS toxicity and inhibits the increase in serum TNF levels in LPS-treated mice, and data indicate that GSH can be an endogenous modulator of TNF production in vivo.
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The CRTC1-SIK1 pathway regulates entrainment of the circadian clock.
Aarti Jagannath,R Butler,R Butler,Godinho Sih.,Godinho Sih.,Yvonne Couch,Laurence A. Brown,Sridhar R. Vasudevan,Kevin C. Flanagan,Daniel C. Anthony,Grant C. Churchill,Wood Mja.,G Steiner,Martin Ebeling,M Hossbach,Joseph G. Wettstein,Giles E. Duffield,Silvia Gatti,Mark W. Hankins,Russell G. Foster,Stuart N. Peirson +20 more
TL;DR: Analysis of the light-regulated transcriptome of the SCN has identified a key role for salt inducible kinase 1 (SIK1) and CREB-regulated transcription coactivator 1 (CRTC1) in clock re-setting and provides a potential target for the regulation of circadian rhythms.
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CTEP: A Novel, Potent, Long-Acting, and Orally Bioavailable Metabotropic Glutamate Receptor 5 Inhibitor
Lothar Lindemann,Georg Jaeschke,Aubin Michalon,Eric Vieira,Michael Honer,Will Spooren,Porter Richard Hugh Phillip,Thomas Hartung,Sabine Kolczewski,Bernd Büttelmann,Christophe Flament,Catherine Diener,Christophe Fischer,Silvia Gatti,Eric Prinssen,Neil Parrott,Gerhard Hoffmann,Joseph G. Wettstein +17 more
TL;DR: CTEP is the first reported mGlu5 inhibitor with both long half-life of approximately 18 h and high oral bioavailability allowing chronic treatment with continuous receptor blockade with one dose every 48 h in adult and newborn animals.