Joffre B. Baker

TL;DR: Experiments probing the mechanism by which glucocorticoids modulate cell proliferation were carried out on serum-free cell cultures of quiescent human diploid foreskin (HF) cells, suggesting a relationship between the dexamethasone effects on binding and growth.

TL;DR: In this article, the authors explored the function of PN by examining the interaction of protease-PN complexes with human fibroblasts and the conse- quences of this interaction.

TL;DR: It is shown that protease nexin I (PNI), a fibroblast-secreted inhibitor of urokinase, plasmin, and certain other serine proteinases, effectively inhibited the HT-1080 cell-mediated degradation of this ECM.

TL;DR: The isolation, sequence, and expression of PNI cDNA cloned from a human foreskin fibroblast cDNA library is described and the amino acid sequence of βPNI is identical to that of a recently described glial–derived neurite promoting factor.

TL;DR: In confluent cultures normal chick embryo fibroblasts become highty agglutinable by concanavalin A within 6 hours after their synthesis of protein is inhibited by cycloheximide, pactamycin, or emetine, but when growing cells are similarly treated, they fail to become more agglUTinable.