T
Tom Humphreys
Researcher at University of Hawaii
Publications - 88
Citations - 3790
Tom Humphreys is an academic researcher from University of Hawaii. The author has contributed to research in topics: Hemichordate & Messenger RNA. The author has an hindex of 38, co-authored 85 publications receiving 3655 citations. Previous affiliations of Tom Humphreys include Kyoto University & Panthera Corporation.
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Journal ArticleDOI
Characterization of sponge aggregation factor. A unique proteoglycan complex.
Journal ArticleDOI
Hemichordate genomes and deuterostome origins
Oleg Simakov,Takeshi Kawashima,Ferdinand Marlétaz,Jerry Jenkins,Ryo Koyanagi,Therese Mitros,Kanako Hisata,Jessen V. Bredeson,Eiichi Shoguchi,Fuki Gyoja,Jia-Xing Yue,Yi Chih Chen,Robert Freeman,Akane Sasaki,Tomoe Hikosaka-Katayama,Atsuko Sato,Manabu Fujie,Kenneth W. Baughman,Judith Levine,Paul Gonzalez,Christopher B. Cameron,Jens H. Fritzenwanker,Ariel M. Pani,Hiroki Goto,Miyuki Kanda,Nana Arakaki,Shinichi Yamasaki,Jiaxin Qu,Andrew Cree,Yan Ding,Huyen Dinh,Shannon Dugan,Michael Holder,Shalini N. Jhangiani,Christie Kovar,Sandra L. Lee,Lora Lewis,Donna Morton,Lynne V. Nazareth,Geoffrey Okwuonu,Jireh Santibanez,Rui Chen,Stephen Richards,Donna M. Muzny,Andrew Gillis,Leonid Peshkin,Michael Wu,Tom Humphreys,Yi-Hsien Su,Nicholas H. Putnam,Jeremy Schmutz,Asao Fujiyama,Jr-Kai Yu,Kunifumi Tagawa,Kim C. Worley,Richard A. Gibbs,Marc W. Kirschner,Christopher J. Lowe,Noriyuki Satoh,Daniel S. Rokhsar,Daniel S. Rokhsar,Daniel S. Rokhsar,John C. Gerhart +62 more
TL;DR: The draft genome sequences of two acorn worms are reported, identifying shared traits that were probably inherited from the last common deuterostome ancestor, and exploring evolutionary trajectories leading from this ancestor to hemichordates, echinoderms and chordates.
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Development of a recombinant tetravalent dengue virus vaccine: immunogenicity and efficacy studies in mice and monkeys.
David E. Clements,Beth-Ann Coller,Michael M. Lieberman,Steven Ogata,Gordon V.L. Wang,Kent E. Harada,J. Robert Putnak,John M. Ivy,Michael Mcdonell,Gary S. Bignami,Iain Peters,Julia Leung,Carolyn Weeks-Levy,Eileen T. Nakano,Tom Humphreys +14 more
TL;DR: Results support the development of a dengue virus tetravalent vaccine based on the four 80E subunits produced in the Drosophila S2 cell expression system, which are highly immunogenic and capable of eliciting protective responses in both mice and monkeys.
Journal ArticleDOI
An analysis of the partial metabolic derepression of sea urchin eggs by ammonia: The existence of independent pathways
TL;DR: It is found that ammonia activation does not result in the early respiratory burst and also does not initiate the late activation of Na+-dependent amino acid transport, indicating that augmentation of protein synthesis is causally linked neither to the earlier Na-influx, cortical reactions, and respiratory burst nor to the later activation of amino acid Transport.
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An evaluation of dengue type-2 inactivated, recombinant subunit, and live-attenuated vaccine candidates in the rhesus macaque model.
J. Robert Putnak,Beth-Ann Coller,Gerald Voss,David W. Vaughn,David E. Clements,Iain Peters,Gary S. Bignami,Hou-Shu Houng,Robert Chung-Ming Chen,David A. Barvir,Jitvimol Seriwatana,Sylvie Cayphas,Nathalie Garçon,Dirk Gheysen,Niranjan Kanesa-thasan,Mike McDonell,Tom Humphreys,Kenneth H. Eckels,Jean-Paul Prieels,Bruce L. Innis,Bruce L. Innis +20 more
TL;DR: Several groups exhibited nearly complete protection against viremia by bioassay, although there was evidence for challenge virus replication by Taqmantrade mark and immunological assays, and none of the vaccines conferred sterile immunity.