Johan Högberg

TL;DR: It is concluded that major interethnic differences exist in the genetic polymorphism of CYP2E1 and that people carrying the mutated allele (c2) among the lung cancer patients as compared to controls might be at lower risk for developing lung cancer.

TL;DR: Data from isolated hepatocyte model systems indicate a modulating role for DNA damage in selenite cytotoxicity mediated by poly(ADP-ribose)polymerase and suggest that cell death resulted from interactions between several events that may deplete energy supplies.

TL;DR: Monitoring MDA excretion in urine can give useful information about lipid peroxidation in vivo, and the peak urinary concentration approached the expected plasma concentration and reproducible recovery data were obtained, suggesting that MDA was passively excreted in a reasonably stable form.

TL;DR: It is concluded that the foci data provide no evidence for an involvement of redox cycles in hydroquinone-induced development of enzyme-altered foci, and in vitro data indicate a mechanism by which GSH depletion and toxicity may induce this effect.

TL;DR: It is suggested that GST-P-positive cells lack functional p53 protein and that this permits cells with damaged DNA to replicate and is eliminated by p53 antisense oligonucleotides.