J
Johan N. M. Heersche
Researcher at University of Toronto
Publications - 78
Citations - 5027
Johan N. M. Heersche is an academic researcher from University of Toronto. The author has contributed to research in topics: Bone resorption & Bone cell. The author has an hindex of 35, co-authored 78 publications receiving 4904 citations. Previous affiliations of Johan N. M. Heersche include St. Michael's Hospital.
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Mineralized bone nodules formed in vitro from enzymatically released rat calvaria cell populations.
TL;DR: The results indicated that enzymatically released calvaria cells can form mineralized bone nodules in vitro in the presence of ascorbic acid and organic phosphate.
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Parathyroid Hormone Stimulates the Bone Apposition Rate Independently of Its Resorptive Action: Differential Effects of Intermittent and Continuous Administration
TL;DR: The results suggest that the resorptive effects of bPTH-(1-84) can be separated from the effects of the hormone on the apposition rate, and also found an increase in both formation and resorption surfaces and a net decrease in the trabecular bone volume in this group.
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Initiation and progression of mineralization of bone nodules formed in vitro: the role of alkaline phosphatase and organic phosphate
TL;DR: In this article, the authors show that the initiation and progression of bone nodule mineralization are separate phenomena and that organic phosphate and alkaline phosphatase play a crucial role in the initiation of mineralization.
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Differentiation of osteoblasts and formation of mineralized bone in vitro.
TL;DR: Periostea consisting of the osteogenic layer and the fibrous layer of the periosteum were dissected from 17-day-old embryonic chick calvariae, and physiologic mineralization of osteoid produced in vitro did occur in this system by the addition of the alkaline phosphatase substrateβ-glycerophosphate.
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Glucocorticoid-induced osteoporosis : Both in vivo and in vitro concentrations of glucocorticoids higher than physiological levels attenuate osteoblast differentiation
TL;DR: The diverse and complex effects of GCs on bone metabolism are still incompletely understood, mainly due to differences in experimental outcomes in different systems and culture conditions, which could be a result of species differences, age of the experimental animals used, maturation stage of the cells studied, heterogeneity of osteoblast populations, differences between transformed cells and normal cells, or length and dose of GC treatment used.