Showing papers in "Bone and Mineral in 1991"

TL;DR: Ovariectomy induced bone loss in the rat and postmenopausal bone loss share many similar characteristics, including: increased rate of bone turnover with resorption exceeding formation; and initial rapid phase of bone loss followed by a much slower phase.

TL;DR: In this article, the authors show that the initiation and progression of bone nodule mineralization are separate phenomena and that organic phosphate and alkaline phosphatase play a crucial role in the initiation of mineralization.

TL;DR: Six healthy active women, aged 28-34, had bone mineral density measured (DPA & SPA) at seven sites prior to pregnancy, within 6 weeks of parturition, and after 6 months of lactation, to represent changes in mechanical stress as a result of weight gain, changes in posture and/or activity.

TL;DR: The low to very high doses of estradiol used in this study decreased the progression of the bone loss due to ovariectomy by suppression of the rate of bone turnover that involved the depression of both osteoclastic resorption and osteoblastic bone formation.

TL;DR: Collagen X gene expression was detected in chrondrocytes present in OA tissue in areas where there appeared to be a re-initiation of the endochondral bone formation process including osteophytes and areas of subchondral bone sclerosis.

TL;DR: There were no significant changes in static parameters measuring total bone tissue, osteoclastic function or osteoid formation after two cycles of treatment, but there was a significant increase in the activation frequency.

TL;DR: The results indicate that PTH and PGE2 inhibit osteocalcin secretion by a mechanism involving cAMP production, and the human osteosarcoma cell line MG-63 is a useful osteoblast-like cell model to study the regulation of osteoccin secretion.

TL;DR: The findings indicate that in estrogen deficiency, tamoxifen has a weak estrogen agonist action on bone, and in the presence of estrogen it has anti-estrogen actions, with the dose level and mode of administration employed.

TL;DR: Observations indicate that the powerful anabolic effects of PGE2 will increase both periosteal and corticoendosteal bone mass and sustain the transient increase in bone mass with continuous daily administration of P GE2.

TL;DR: It is concluded that there is an early significant increment in resorption parameters, with a slow return during the mobilization period, and serum 1,25-dihydroxyvitamin D is suppressed as a result of the increased serum calcium and serum phosphate levels.

TL;DR: This paper describes the reconstruction of the remodelling cycle in normal iliac crest cortical bone from static and dynamic variables after double labelling with tetracycline in 10 young normal individuals, indicating an initial osteoclastic resorption phase preceding a mononuclear resOrption phase.

TL;DR: It is concluded that intermittent treatment with AHBuBP is capable of increasing spinal BMD and conserving radial BMD in postmenopausal osteoporosis and may represent a convenient therapeutic choice in this condition.

TL;DR: It is demonstrated that bone cells produce several forms of SPP-1 which are differentially regulated in normal and transformed cells through both transcriptional and posttranscriptional mechanisms.

TL;DR: It is concluded that prolonged moderate alcohol intake impairs osteoblastic function, leading to lowered serum levels of osteocalcin, but it does not derange vitamin D metabolism.

TL;DR: The bone mineral content (BMC) of the mid-shaft radius was measured in 446 rural Gambian and 349 British women aged 18-80+ years using single-photon absorptiometry and the Gambian women had significantly lower BMC than British women of the same age but after adjusting for weight, height and BW, the BMC of Gambia women was shown to be slightly higher than that of British women.

TL;DR: To exclude with certainty the possibility that the intralacunar osteoblasts had derived from remaining periosteal osteoprogenitor cells that invaded the lacunae, the long bones were pre-cultured with cytochalasin D, which inhibits cell proliferation and migration, and proved that the bone matrix producing osteoblast inside the cartilage Lacunae were transdifferentiated chondrocytes.

TL;DR: For monitoring changes in BMD longitudinally, careful repositioning of the foot and leg will be necessary to achieve precision in vivo of less than 1%.

TL;DR: Compared with aminobisphosphonates, tiludronate is not indicated for the treatment of tumor-associated hypercalcemia because of the need for high iv doses which are potentially nephrotoxic.

TL;DR: A significant difference in BMD was found between physically active and sedentary women, but not between the smokers and non-smokers, or the drinkers andnon-drinkers.

TL;DR: Nandrolone decanoate therapy may be used in the prevention of CST-induced osteoporosis because it also seems to exert mild inhibition of bone resorption without affecting or even stimulating bone formation.

TL;DR: It appears that there are several identifiable characteristics among the anthropometric variables which appear to exert differential effects on skeletal development in children.

TL;DR: PTHrP thus mimics the actions of PTH, but is not as effective in promoting mesenchymal cell proliferation along the bone trabeculae.

TL;DR: It is concluded that the mineralized nodules formed in the culture system are truly bone-like and had histological characteristic similar to bone.

TL;DR: Prediction equations for bone width and mineral content based on height and weight are given, which should enhance the application of single photon absorptiometry in clinical practice.

TL;DR: The most elderly men had both the lowest bone mass and the greatest bone loss rates, and the oldest men in the cohort strongly influenced these trends.

TL;DR: The determination of the BMD of the radius shaft by SPA was a sensitive method for detecting abnormalities of the bone mass in XLH patients under treatment without radiological signs of rickets.

TL;DR: Several lines of evidence indicate that the 60K bone glycoprotein is the rat homologue of human α2HS-glycoprotein, which was found to be highly immunogenic and should be considered as a potential problem.

TL;DR: Reductions in stiffness of exercised tibiae were significantly correlated with cross-sectional area, and reduced appositional growth of the periosteal and endosteal surface at the mid-diaphysis of exercisedTibiae showed fewer regions of, measurable, appOSitional growth than controls.

TL;DR: The results suggest that hypergravity stimulates proliferation but suppresses differentiation of osteoblast-like cells through a pathway independent of the activation of protein kinase C and the production of cyclic nucleotides, and that hyper gravity and IGF-I stimulate proliferation of these cells through an independent signal transduction pathway.