Johannes P. Borde

TL;DR: This review summarizes available data on the pathogenesis and clinical features of TBE, plus different vaccine preparations available in Europe and Russia, plus new treatment possibilities, including small molecule drugs and experimental immunotherapies are reviewed.

TL;DR: QoL is substantially reduced after a prosthetic infection, and it is observed that post-Girdelstone procedure patients or those with an arthrodesis attained an acceptable QoL, and that those methods remain therapeutic alternatives as far as patient-perceived QOL is concerned.

TL;DR: It is indicated that the applied approach to the antibiotic stewardship bundle approach is feasible and is accompanied by a significant reduction of in-hospital mortality in the secondary care setting, and may serve as a model for other hospitals with similar structures and baseline situations.

TL;DR: This pilot study gave no indication of superiority of the used NAATs over conventional culture methods for the microbiological diagnosis of PJI, and draws are susceptibility to contamination in the case of 16S rRNA gene real-time PCR, labour-intensive DNA extraction and limited pathogen panel in the cases of the multiplex cartridge PCR system.

TL;DR: The data demonstrate that implementation of an ASP was associated with a profound improvement of rational antibiotic use and, therefore, patient safety, and considering the relatively short observation period, the long-term effects of the ASP bundle need to be further investigated.