Ivan S. Kholodilov

TL;DR: This review summarizes available data on the pathogenesis and clinical features of TBE, plus different vaccine preparations available in Europe and Russia, plus new treatment possibilities, including small molecule drugs and experimental immunotherapies are reviewed.

TL;DR: Alongshan virus (ALSV), which is a representative of the JMV group, is detected in ten pools of adult Ixodes persulcatus ticks collected in two geographically-separated Russian regions.

TL;DR: It was shown that after a course of two immunizations, factors such as the period between vaccinations, the challenging virus dose and terms of challenge did not significantly affect the assessment of protective efficacy of the vaccine in vivo.

TL;DR: Evaluated the selective pressure on the TBEV population during persistent infection of various species of ticks and tick cell lines to find virus variants with properties of the original strain adapted to mouse CNS were not eliminated from the viral population during long-term persistence.

TL;DR: The value of tick cell lines in virus isolation and maintenance of persistent infection is confirmed and evidence for the existence of a novel upstream ORF in the glycoprotein-coding segment of ALSV and other members of the Jingmen tick virus group is found.