J
Johannes P. F. G. Helsper
Researcher at Wageningen University and Research Centre
Publications - 15
Citations - 1285
Johannes P. F. G. Helsper is an academic researcher from Wageningen University and Research Centre. The author has contributed to research in topics: Phellinus linteus & Agaricus bisporus. The author has an hindex of 13, co-authored 15 publications receiving 1122 citations.
Papers
More filters
Journal ArticleDOI
Antioxidative and immunomodulating activities of polysaccharide extracts of the medicinal mushrooms Agaricus bisporus, Agaricus brasiliensis, Ganoderma lucidum and Phellinus linteus
Maja Kozarski,Maja Kozarski,Anita Klaus,Miomir Nikšić,Dragica Jakovljević,Johannes P. F. G. Helsper,L.J.L.D. van Griensven +6 more
TL;DR: Partially purified polysaccharides were obtained from four medicinal mushroom species, Agaricus bisporus, A. brasiliensis, Phellinus linteus and Ganoderma lucidum by hot water extraction, followed by ethanol precipitation as mentioned in this paper.
Journal ArticleDOI
Polyunsaturated fatty acids in various macroalgal species from north Atlantic and tropical seas
Vincent van Ginneken,Johannes P. F. G. Helsper,Willem de Visser,Herman van Keulen,Willem A Brandenburg +4 more
TL;DR: Marine macroalgae form a good, durable and virtually inexhaustible source for polyunsaturated fatty acids with an (n-6) FA: ( n-3) FA ratio of about 1.0.
Journal ArticleDOI
An antibody produced in tobacco expressing a hybrid beta-1,4-galactosyltransferase is essentially devoid of plant carbohydrate epitopes.
Hans Bakker,Gerard J. A. Rouwendal,Anton S. Karnoup,Dion E.A. Florack,Geert Stoopen,Johannes P. F. G. Helsper,Ronald van Ree,Irma van Die,Dirk Bosch,Dirk Bosch +9 more
TL;DR: It is demonstrated that expression of a hybrid enzyme in tobacco causes a sharp reduction of N-glycans with potentially immunogenic core-bound xylose and fucose residues, which suggests that a transgenic plant expressing the hybrid GalT might yield more effective and safer monoclonals for therapeutic purposes than WT plants and even transgenic plants expressing the unchanged GalT.
Journal ArticleDOI
Translocation of differently sized and charged polystyrene nanoparticles in in vitro intestinal cell models of increasing complexity.
Agata P. Walczak,Evelien Kramer,Peter J.M. Hendriksen,Peter C. Tromp,Johannes P. F. G. Helsper,Meike van der Zande,Ivonne M.C.M. Rietjens,Hans Bouwmeester +7 more
TL;DR: Using one intestinal model is sufficient for comparing the relative translocation of different NPs, to choose the most representative model for risk assessment, in vivo experiments are now needed to determine the in vivo translocation rates of the used NPs.
Journal ArticleDOI
Effects of mushroom-derived beta-glucan-rich polysaccharide extracts on nitric oxide production by bone marrow-derived macrophages and nuclear factor-kappaB transactivation in Caco-2 reporter cells: Can effects be explained by structure?
Julia J. Volman,Johannes P. F. G. Helsper,Song Wei,Johan J. P. Baars,Leo J.L.D. Van Griensven,Anton S.M. Sonnenberg,Ronald P. Mensink,Jogchum Plat +7 more
TL;DR: Characteristics of A. bisporus make it an attractive candidate as a nutritional compound to stimulate the immune response in depressed states of immunity, and branching of the beta-glucan chain is essential for immune-stimulating activity.