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Johannes P. F. G. Helsper

Researcher at Wageningen University and Research Centre

Publications -  15
Citations -  1285

Johannes P. F. G. Helsper is an academic researcher from Wageningen University and Research Centre. The author has contributed to research in topics: Phellinus linteus & Agaricus bisporus. The author has an hindex of 13, co-authored 15 publications receiving 1122 citations.

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Antioxidative and immunomodulating activities of polysaccharide extracts of the medicinal mushrooms Agaricus bisporus, Agaricus brasiliensis, Ganoderma lucidum and Phellinus linteus

TL;DR: Partially purified polysaccharides were obtained from four medicinal mushroom species, Agaricus bisporus, A. brasiliensis, Phellinus linteus and Ganoderma lucidum by hot water extraction, followed by ethanol precipitation as mentioned in this paper.
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Polyunsaturated fatty acids in various macroalgal species from north Atlantic and tropical seas

TL;DR: Marine macroalgae form a good, durable and virtually inexhaustible source for polyunsaturated fatty acids with an (n-6) FA: ( n-3) FA ratio of about 1.0.
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An antibody produced in tobacco expressing a hybrid beta-1,4-galactosyltransferase is essentially devoid of plant carbohydrate epitopes.

TL;DR: It is demonstrated that expression of a hybrid enzyme in tobacco causes a sharp reduction of N-glycans with potentially immunogenic core-bound xylose and fucose residues, which suggests that a transgenic plant expressing the hybrid GalT might yield more effective and safer monoclonals for therapeutic purposes than WT plants and even transgenic plants expressing the unchanged GalT.
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Translocation of differently sized and charged polystyrene nanoparticles in in vitro intestinal cell models of increasing complexity.

TL;DR: Using one intestinal model is sufficient for comparing the relative translocation of different NPs, to choose the most representative model for risk assessment, in vivo experiments are now needed to determine the in vivo translocation rates of the used NPs.
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Effects of mushroom-derived beta-glucan-rich polysaccharide extracts on nitric oxide production by bone marrow-derived macrophages and nuclear factor-kappaB transactivation in Caco-2 reporter cells: Can effects be explained by structure?

TL;DR: Characteristics of A. bisporus make it an attractive candidate as a nutritional compound to stimulate the immune response in depressed states of immunity, and branching of the beta-glucan chain is essential for immune-stimulating activity.