J
John A. Lucas
Researcher at Mayo Clinic
Publications - 87
Citations - 5650
John A. Lucas is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Dementia & Cognition. The author has an hindex of 33, co-authored 83 publications receiving 5198 citations. Previous affiliations of John A. Lucas include Kettering University & University of Innsbruck.
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Journal ArticleDOI
Detecting Dementia With the Mini-Mental State Examination in Highly Educated Individuals
Sid E. O'Bryant,Joy D. Humphreys,Glenn E. Smith,Robert J. Ivnik,Neill R. Graff-Radford,Ronald C. Petersen,John A. Lucas +6 more
TL;DR: Older patients with a college education who present with complaints of cognitive decline and score less than 27 on the MMSE are at a greater risk of being diagnosed with dementia and should be referred for a comprehensive dementia evaluation, including formal neuropsychological testing.
Journal ArticleDOI
Association of REM sleep behavior disorder and neurodegenerative disease may reflect an underlying synucleinopathy.
TL;DR: Whether rapid eye movement (REM) sleep behavior disorder occurs in disproportionally greater frequency in multiple system atrophy, Parkinson's disease, and dementia with Lewy bodies, collectively known as the synucleinopathies, compared to other nonsynucleinopathy neurodegenerative disorders is examined.
Journal ArticleDOI
Association of Low Plasma Aβ42/Aβ40 Ratios With Increased Imminent Risk for Mild Cognitive Impairment and Alzheimer Disease
Neill R. Graff-Radford,Julia E. Crook,John A. Lucas,Bradley F. Boeve,David S. Knopman,Robert J. Ivnik,Glenn E. Smith,Linda H. Younkin,Ronald C. Petersen,Steven G. Younkin +9 more
TL;DR: The plasma Aβ42/Aβ40 ratio may be a useful premorbid biomarker for identifying cognitively normal elderly white subjects who are at increased risk for developing MCI or AD.
Journal ArticleDOI
Characterization of frontotemporal dementia and/or amyotrophic lateral sclerosis associated with the GGGGCC repeat expansion in C9ORF72
Bradley F. Boeve,Kevin B. Boylan,Neill R. Graff-Radford,Mariely DeJesus-Hernandez,David S. Knopman,Otto Pedraza,Prashanthi Vemuri,David T.W. Jones,Val J. Lowe,Melissa E. Murray,Dennis W. Dickson,Keith A. Josephs,Beth K. Rush,Mary M. Machulda,Julie A. Fields,Tanis J. Ferman,Matt Baker,Nicola J. Rutherford,Jennifer Adamson,Zbigniew K. Wszolek,Anahita Adeli,Rodolfo Savica,Brendon P. Boot,Karen M. Kuntz,Ralitza H. Gavrilova,Andrew L. Reeves,Jennifer L. Whitwell,Kejal Kantarci,Clifford R. Jack,Joseph E. Parisi,John A. Lucas,Ronald C. Petersen,Rosa Rademakers +32 more
TL;DR: Most cases with this mutation have a characteristic spectrum of demographic, clinical, neuropsychological, neuroimaging and especially neuropathological findings; no case had strikingly focal or asymmetric findings.
Journal ArticleDOI
Validation of the Mayo Sleep Questionnaire to screen for REM sleep behavior disorder in an aging and dementia cohort
Bradley F. Boeve,Jennifer R. Molano,Tanis J. Ferman,Glenn E. Smith,Siong Chi Lin,Kevin F. Bieniek,Wael N. Haidar,Maja Tippmann-Peikert,David S. Knopman,Neill R. Graff-Radford,John A. Lucas,Ronald C. Petersen,Michael H. Silber +12 more
TL;DR: Data suggest that among aged subjects with cognitive impairment and/or parkinsonism, the MSQ has adequate SN and SP for the diagnosis of RBD, and the utility of this scale in other patient populations will require further study.