J
John A. Rupley
Researcher at University of Arizona
Publications - 50
Citations - 4716
John A. Rupley is an academic researcher from University of Arizona. The author has contributed to research in topics: Lysozyme & Percolation. The author has an hindex of 26, co-authored 50 publications receiving 4546 citations.
Papers
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Journal ArticleDOI
Environment and exposure to solvent of protein atoms. Lysozyme and insulin.
A. Shrake,John A. Rupley +1 more
TL;DR: A computer program is described for calculating the environment and the exposure to solvent of atoms of a protein based on the atomic co-ordinates of the protein and on assumptions like those of Lee & Richards (1971).
Book ChapterDOI
Protein hydration and function.
John A. Rupley,Giorgio Careri +1 more
TL;DR: This chapter summarizes the literature that bears on the protein hydration process and the hydration shell, categorized by type of measurement, and provides picture of the hydrated shell and an assessment of the ways in which thehydration shell may modulate enzyme and other protein functions.
Journal ArticleDOI
Water and globular proteins
TL;DR: In this article, dynamic, thermodynamic and structural studies of the hydration of globular proteins indicate how the macromolecule-water interface can influence folding, enzymatic activity and other biological properties.
Book ChapterDOI
21 Vertebrate Lysozymes
TL;DR: This chapter focuses on vertebrate lysozymes, particularly hen egg-white (HEW) lysozyme, which is small and basic, and it separates well on weak acid resins, like Amberlite XE-64 or Bio-Rex 70 or carboxymethyl cellulose and on calcium phosphate gel.
Journal ArticleDOI
Fluorescence of lysozyme: emissions from tryptophan residues 62 and 108 and energy migration.
TL;DR: By examination of the fluorescence of derivatives in which Trp 62 and/or Trp 108 are specifically oxidized, it has been possible to detect a pH-dependent interaction between tryptophan residues.