J
John D. Catravas
Researcher at Old Dominion University
Publications - 254
Citations - 8793
John D. Catravas is an academic researcher from Old Dominion University. The author has contributed to research in topics: Lung injury & Angiotensin-converting enzyme. The author has an hindex of 47, co-authored 234 publications receiving 7767 citations. Previous affiliations of John D. Catravas include College of Health Sciences, Bahrain & Yale University.
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Journal ArticleDOI
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study
Paul E. Marik,Vikramjit Khangoora,Racquel Rivera,Michael H. Hooper,John D. Catravas,John D. Catravas +5 more
TL;DR: The results suggest that the early use of intravenous vitamin C, together with corticosteroids and thiamine, are effective in preventing progressive organ dysfunction, including acute kidney injury, and in reducing the mortality of patients with severe sepsis and septic shock.
Journal ArticleDOI
Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19).
Ruben Manuel Luciano Colunga Biancatelli,Ruben Manuel Luciano Colunga Biancatelli,Ruben Manuel Luciano Colunga Biancatelli,Max Berrill,John D. Catravas,John D. Catravas,John D. Catravas,Paul E. Marik +7 more
TL;DR: The current evidence for the use of vitamin C and quercetin both for prophylaxis in high-risk populations and for the treatment of COVID-19 patients as an adjunct to promising pharmacological agents such as Remdesivir or convalescent plasma is presented.
Journal ArticleDOI
Nitric oxide and the endothelium: history and impact on cardiovascular disease.
TL;DR: There is tremendous promise behind NO itself as well as the numerous other molecules and processes associated with the L-arginine-NO-cGMP pathway, but collaborative efforts among bench scientists, clinical investigators and epidemiologists are the key in realizing this promise.
Journal ArticleDOI
Long-term antioxidant administration attenuates mineralocorticoid hypertension and renal inflammatory response.
Richard A. Beswick,Richard A. Beswick,Hanfang Zhang,Dawnyetta Marable,John D. Catravas,William D. Hill,R. Clinton Webb +6 more
TL;DR: It is suggested that antioxidants attenuate systolic blood pressure, suppress renal NF-&kgr;B–binding activity, and partly alleviate renal monocyte/macrophage infiltration in DOCA-salt hypertension.
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Endothelial nitric oxide (NO) and its pathophysiologic regulation.
TL;DR: The transcriptional regulation of endothelial NOS and factors affecting eNOS activity and function are reviewed, as well as the important vascular pathologies associated with altered NOS function, focusing on the regulatory role of hsp90 and other factors in NO-associated pathogenesis of these diseases.