Showing papers by "John E. Christian published in 1949"
TL;DR: A new method for the quantitative determination of human and animal surface lipids is described and average lipid values for men and women have been determined and frequency distribution curves are presented.
Abstract: A new method for the quantitative determination of human and animal surface lipids is described. Average lipid values for men and women have been determined and frequency distribution curves are presented. The effects of soaps, astringents, and temperature on the lipid production of human beings have been studied. The action of sex hormones, thyroxin, and thiouracil on the sebaceous gland activity of the albino rat has also been considered.
8 citations
TL;DR: Results indicated that absorption of this salt was greater from white petrolatum than from either wool fat or lard, and the white rat was used as the test animal.
Abstract: The results of a study of the comparative absorption of radioactive sodium iodide from lard, wool fat, and petrolatum are reported, The results indicated that absorption of this salt was greater from white petrolatum than from either wool fat or lard. The white rat was used as the test animal.
6 citations
TL;DR: The syntheses of several methoxy derivatives of pyridine are described and it is suggested that this group may be responsible for the emetic action of these compounds.
Abstract: Since the methoxy group is present in emetine, in a patented emetic, and in several nauseant benzene derivatives it is possible that this group may be responsible for the emetic action of these compounds. In this report the syntheses of several methoxy derivatives of pyridine are described.
4 citations
TL;DR: A summary is presented of the results of a study of the absorption of radioactive sodium iodide from 37 ointment bases of varying composition, where the salt was most efficiently absorbed from wool fat.
Abstract: A summary is presented of the results of a study of the absorption of radioactive sodium iodide from 37 ointment bases of varying composition. Absorption from half of the bases was equally as good as from lard. The other half of the bases proved to be less efficient than lard from the point of view of absorption. The salt was most efficiently absorbed from wool fat. The white rat was used as the test animal.
3 citations
TL;DR: Polarographic reduction of diethylstilbestrol was not found to occur under the conditions studied, and the idea of developing a polarographic assay for this and other synthetic estrogens was abandoned.
Abstract: Studies on the polarographic properties of diethylstilbestrol were carried out, with the idea of developing a polarographic assay for this and other synthetic estrogens. Polarographic reduction of diethylstilbestrol was not found to occur under the conditions studied. Minute quantities of the estrogen suppress the oxygen maximum in a solution of potassium chloride, the degree of suppression being approximately proportional to the concentration of diethylstilbestrol within a narrow range. This property is the basis for a suggested assay of preparations of diethylstilbestrol.
2 citations
TL;DR: Seven aromatic thiols have been used to prepare two series of sulfides, analogous to Benadryl and Pyribenzamine type compounds with sulfur replacing the oxygen and nitrogen, respectively.
Abstract: Seven aromatic thiols have been used to prepare two series of sulfides. Thiols used were o-thiophenol, o-thiocresol, m-thiocresol, p-thiocresol, o-chlorobenzyl thiol, 2,4-dichiorobeazyl thiol, and 3,4-dichlorobenzyi thiol. A series was prepared of 3-diethyl-aminopropyl derivatives and 3rdiethylamino-2-propanol derivatives. The compounds are analogous to Benadryl and Pyribenzamine type compounds with sulfur replacing the oxygen and nitrogen, respectively. The general structure of the molecule differs from these antihistamine drugs in that only one aryl group is present instead of the diaryl groups of Benadryl and Pyribenzamine. The aryl structure was varied to show the influence of substituent groups, in order that some of the thiols used would contain chlorine on the ring; others would contain methyl groups.
1 citations
TL;DR: A new technique using radioactive isotopes as tracer elements in the study of the effect of various solutions on the teeth is described and applications of the method are stressed.
Abstract: Rat incisors become radioactive when labeled phosphorus is injected iniraperitoneally. A new technique using radioactive isotopes as tracer elements in the study of the effect of various solutions on the teeth is described. Applications of the method are stressed.
TL;DR: A method for the preliminary evaluation of radiographic opaques in vitro uses X-ray film, photometric absorption cells containing opaque media, and aluminum strips of varying density as reference standards and a relationship between chemical composition and opacity has been found.
Abstract: A method for the preliminary evaluation of radiographic opaques in vitro has been developed. The method employs a device holding X-ray film, photometric absorption cells containing opaque media, and aluminum strips of varying density as reference standards. The method eliminates sources of error such as thickness of solution layer and exposure and developing times. No relationship between chemical structure and opacity was found in a series of compounds. A relationship between chemical composition and opacity has been found.