A new T7-specific RNA polymerase is found in T7 phage-infected cells It is the product of T7 gene I and is physically and biochemically distinct from the host cell RNA polymerase The synthesis of T7 RNA polymerase provides a direct explanation for the pleiotropic control of late T7 functions exerted by gene I

New RNA polymerase from Escherichia coli infected with bacteriophage T7.

INTRODUCTION............................................................ 290 ACTION ON BACTERIA.................................................... 291 General Effects of Rifamycins In Vivo and In Vitro.............................. 291 Interaction of Rifamycins with DNA-Dependent RNA Polymerase (EC 2.7.7.6.) ..... ... 291 Characterization of RNA polymerase......................................... 291 Various steps of the RNA polymerase reaction................................. 291 Structure of RNA polymerase............................................... 292 Which enzymatic step is inhibited by rifamycins?.............................. 292 Complex formation of rifamycins with RNA polymerase......................... 293 Resistance Against the Action of Rifamycins.................................... 293 Relationship Between the Chemical Structure and Biological Activity of the Various Rifamycin Derivatives....................................................... 295 Rifamycins as a Tool in Biochemical Studies.................................... 297 Mode of Interaction Between Rifamycins and Bacterial RNA Polymerase ..... ....... 297 Nature of the enzyme-rifamycin complex..................................... 297 Relation between rifamycin-enzyme complex and enzyme inhibition ...... ........... 297 ACTION ON EUKARYOTES................................................. 298 ANTIVIRAL ACTIVITIES .................................................... 299 Effects on Bacterial Viruses 299 Effects on Mammalian Viruses................................................ 300 Effects on DNA Viruses..................................................... 300 Effects on RNA Viruses..................................................... 301 Effects on Trachoma Agent................................................... 301 CLINICAL APPLICATIONS.................................................. 302 COMPOUNDS RELATED TO THE RIFAMYCINS ............................ 302 SUMMARY AND CONCLUSIONS........................................... 304 LITERATURE CITED........................................................ 304

https://mmbr.asm.org/content/mmbr/35/3/290.full.pdf

Actions of the rifamycins.

Regulation of the appearance of cytoplasmic RNAs from region 1 of the adenovirus 2 genome.

https://mmbr.asm.org/content/mmbr/40/4/847.full.pdf

John F. Pulitzer

Papers

Controls and polarity of transcription during bacteriophage T4 development

Function of T4 gene 55: II. RNA synthesis by temperature-sensitive gene 55 mutants

Function of T4 gene 55. I. Characterization of temperature-sensitive mutations in the "maturation" gene 55.

Relationship between gene 55 function, late transcription and an intermediate in the replication of bacteriophage T4 DNA.