J
John G. Marriott
Researcher at Parke-Davis
Publications - 13
Citations - 268
John G. Marriott is an academic researcher from Parke-Davis. The author has contributed to research in topics: Cognition & Bicyclic molecule. The author has an hindex of 7, co-authored 13 publications receiving 264 citations.
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Journal ArticleDOI
Amnesia-reversal activity of a series of cyclic imides.
Donald E. Butler,James D. Leonard,Bradley William Caprathe,Yvon J. L'Italien,Michael R. Pavia,Fred M. Hershenson,Paul H. Poschel,John G. Marriott +7 more
TL;DR: Compound 3 (CI-911; rolziracetam) was selected for evaluation in cognitively impaired human subjects on the basis of its biological profile and a wide margin of safety in animals.
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Cognition-activating properties of 3-(aryloxy)pyridines
TL;DR: 3-Phenoxypyridine (1) was clearly superior to all of the analogues tested in terms of the level of retention, grammometric potency, and the breadth of its inverted U-shaped dose-response curve.
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Modified di- and tripeptides of the C-terminal portion of oxytocin and vasopressin as possible cognition activation agents.
Ernest D. Nicolaides,Francis J. Tinney,James Stanley Kaltenbronn,Joseph T. Repine,D. A. Dejohn,Elizabeth A. Lunney,William Howard Roark,John G. Marriott,R. E. Davis,Voigtman Re +9 more
TL;DR: A number of peptides and modified peptides were synthesized and studied for their ability to reverse electroconvulsive shock-induced amnesia in rodents, but the chosen compounds failed to show significant activity in enhancing memory.
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Amnesia-reversal activity of a series of N-[(disubstituted-amino)alkyl] -2-oxo-1-pyrrolidineacetamides, including pramiracetam.
Donald E. Butler,Nordin Ivan C,Yvon J. L'Italien,Lynette Zweisler,Paul H. Poschel,John G. Marriott +5 more
TL;DR: A series of N-[(dialkylamino)alkyl]-2-oxo-1- pyrrolidineacetamides was synthesized in this paper and the title compounds reversed electroconvulsive shock (ECS) induced amnesia in mice when administered subsequent to the ECS treatment and were inactive in a general observational test for central nervous system (CNS) activity.
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Water-maze learning and effects of cholinergic drugs in mouse strains with high and low hippocampal pyramidal cell counts
TL;DR: Data suggest a prominent role for the hippocampus in the learning of spatially oriented behavior, and this behavior appears to be responsive to cholinergic manipulations.