J
John G. McCarron
Researcher at Strathclyde Institute of Pharmacy and Biomedical Sciences
Publications - 90
Citations - 2681
John G. McCarron is an academic researcher from Strathclyde Institute of Pharmacy and Biomedical Sciences. The author has contributed to research in topics: Ryanodine receptor & Endothelium. The author has an hindex of 30, co-authored 83 publications receiving 2379 citations. Previous affiliations of John G. McCarron include University of Strathclyde & University of Glasgow.
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Journal ArticleDOI
From Structure to Function: Mitochondrial Morphology, Motion and Shaping in Vascular Smooth Muscle
John G. McCarron,Calum Wilson,Mairi E. Sandison,Marnie L. Olson,John M. Girkin,Christopher D. Saunter,Susan Chalmers +6 more
TL;DR: Three aspects of mitochondrial behaviour are described: morphology, motion and rapid shape changes; the proposed physiological roles to which various mitochondrial arrangements contribute and difficulties in interpreting some of the physiological conclusions.
Journal ArticleDOI
Myogenic contraction by modulation of voltage-dependent calcium currents in isolated rat cerebral arteries.
TL;DR: It is concluded that modest increases in [Ca2+]i within the range 100‐200 nM can account for that myogenic contraction, and that stretch‐evoked modulation of Ca2+ currents may contribute to the myogenic response.
Journal ArticleDOI
The mitochondrial membrane potential and Ca2+ oscillations in smooth muscle
Susan Chalmers,John G. McCarron +1 more
TL;DR: Individual mitochondria within smooth muscle cells might depolarize during repetitive Ca2+ oscillations or during oxidative stress but not during the course of single [Ca2+]c transients evoked by Ca2- influx or store release.
Journal ArticleDOI
Selective uncoupling of individual mitochondria within a cell using a mitochondria-targeted photoactivated protonophore
Susan Chalmers,Stuart T. Caldwell,Caroline Quin,Tracy A. Prime,Andrew M. James,Andrew G. Cairns,Michael P. Murphy,John G. McCarron,Richard C. Hartley +8 more
TL;DR: Depolarization of an individual mitochondrion or small clusters of mitochondria within cells has been achieved using a photoactivatable probe using an alkyltriphenylphosphonium lipophilic cation and the protonophore 2,4-dinitrophenol locally in predetermined regions in response to directed irradiation with UV light via a local photolysis system.
Journal ArticleDOI
Ca2+ microdomains in smooth muscle
TL;DR: The generation of microdomains arising from Ca( 2+) influx across the plasma membrane and the release of the ion from the SR Ca(2+) store will be discussed and the contribution of mitochondria and the Golgi apparatus as well as endogenous modulators (e.g. cADPR and channel binding proteins) will be considered.