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Showing papers by "John H. Cardellina published in 2012"

Journal Article•DOI•
Discovery and preliminary SAR of bisbenzylisoquinoline alkaloids as inducers of C/EBPα

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Paul Klausmeyer1, Thomas G. McCloud1, Dominic A. Scudiero1, Michael J. Currens, John H. Cardellina, Robert H. Shoemaker •
Science Applications International Corporation1
01 Aug 2012-Bioorganic & Medicinal Chemistry
TL;DR: Several of the 28 compounds assayed showed enhancement of C/EBPα induction in U937 cells, which should encourage future efforts toward obtaining and screening a larger set of both natural and synthetic analogs of this interesting group of alkaloids.

7 citations

Patent•
Method of treating HCV infection with a small molecule CHK2 inhibitor

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Christopher Self1, Guangtao Zhang1, Yves Pommier1, Robert H. Shoemaker1, Michael Currens1, John H. Cardellina1, Andrew Jobson1, George T. Lountos1, Dominic A. Scudiero1 •
National Institutes of Health1
26 Oct 2012
TL;DR: In this paper, a method of treating an hepatitis C Virus infection in a patient, comprising providing a therapeutically effective amount, to a patient in need thereof, of a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: G 1 is a group of the formula or where n is 0, 1, 2, 3, or 4 and Het is a 5- or 6-membered heteroaryl group containing 1 to 4 heteroatoms independently chosen from N, O, and S, which is optionally substituted.
Abstract: A method of treating an Hepatitis C Virus infection in a patient, comprising providing a therapeutically effective amount, to a patient in need thereof, of a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: G 1 is a group of the formula or where n is 0, 1, 2, 3, or 4 and Het is a 5- or 6-membered heteroaryl group containing 1 to 4 heteroatoms independently chosen from N, O, and S, which Het is optionally substituted.

1 citations