J
John J. Schlager
Researcher at Air Force Research Laboratory
Publications - 74
Citations - 14377
John J. Schlager is an academic researcher from Air Force Research Laboratory. The author has contributed to research in topics: Silver nanoparticle & Nanotoxicology. The author has an hindex of 41, co-authored 74 publications receiving 13262 citations. Previous affiliations of John J. Schlager include Wright-Patterson Air Force Base & United States Department of the Army.
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In vitro toxicity of nanoparticles in BRL 3A rat liver cells
TL;DR: The microscopic studies demonstrated that nanoparticle-exposed cells at higher doses became abnormal in size, displaying cellular shrinkage, and an acquisition of an irregular shape, which suggested that cytotoxicity of Ag (15, 100 nm) in liver cells is likely to be mediated through oxidative stress.
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Unique cellular interaction of silver nanoparticles: size-dependent generation of reactive oxygen species.
C. Carlson,Saber M. Hussain,Amanda M. Schrand,Laura K. Braydich-Stolle,K. L. Hess,R. L. Jones,John J. Schlager +6 more
TL;DR: A size-dependent toxicity was produced by silver nanoparticles, and one predominant mechanism of toxicity was found to be largely mediated through oxidative stress.
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In Vitro Cytotoxicity of Nanoparticles in Mammalian Germline Stem Cells
TL;DR: The suitability of a mouse spermatogonial stem cell line as a model to assess nanotoxicity in the male germline in vitro is assessed and it is suggested that this cell line provides a valuable model with which to assess the cytotoxicity of nanoparticles in the germ line in vitro.
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Characterization of Nanomaterial Dispersion in Solution Prior to In Vitro Exposure Using Dynamic Light Scattering Technique
Richard C. Murdock,Laura K. Braydich-Stolle,Amanda M. Schrand,John J. Schlager,Saber M. Hussain +4 more
TL;DR: It is demonstrated that many metal and metal oxide nanomaterials agglomerate in solution and that depending upon the solution particleagglomeration is either agitated or mitigated.
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Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner
Adem Kalender,Anand Selvaraj,Anand Selvaraj,So Young Kim,So Young Kim,Pawan Gulati,Sophie Brûlé,Benoit Viollet,Benoit Viollet,Bruce E. Kemp,Nabeel Bardeesy,Patrick B. Dennis,John J. Schlager,André Marette,Sara C. Kozma,Sara C. Kozma,George Thomas,George Thomas +17 more
TL;DR: It is found that the ability of biguanides to inhibit mTORC1 activation and signaling is, instead, dependent on the Rag GTPases.