Saber M. Hussain

TL;DR: The microscopic studies demonstrated that nanoparticle-exposed cells at higher doses became abnormal in size, displaying cellular shrinkage, and an acquisition of an irregular shape, which suggested that cytotoxicity of Ag (15, 100 nm) in liver cells is likely to be mediated through oxidative stress.

TL;DR: The suitability of a mouse spermatogonial stem cell line as a model to assess nanotoxicity in the male germline in vitro is assessed and it is suggested that this cell line provides a valuable model with which to assess the cytotoxicity of nanoparticles in the germ line in vitro.

TL;DR: There are many challenges to overcome before the authors can determine if the benefits outweigh the risks associated with NPs, and some metal-based NPs are showing increased toxicity, even if the same material is relatively inert in its bulk form.

TL;DR: The results indicate that Ag NPs in D. melanogaster induce heat shock stress, oxidative stress, DNA damage and apoptosis, which suggests that the organism is stressed and thus warrants more careful assessment ofAg NPs using in vivo models to determine if chronic exposure presents developmental and reproductive toxicity.

TL;DR: The induction of reactive oxygen species (ROS), degradation of mitochondrial membrane integrity, disruption of the actin cytoskeleton, and reduction in proliferation after stimulation with nerve growth factor were found after incubation with Ag nanoparticles at concentrations of 25 µg ml(-1) or greater, with a more pronounced effect produced by the hydrocarbon-based Ag nanoparticle in most cases.