J
John J. Won
Researcher at University of North Carolina at Chapel Hill
Publications - 6
Citations - 1906
John J. Won is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Virus & Immunology. The author has an hindex of 2, co-authored 4 publications receiving 1482 citations.
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Journal ArticleDOI
Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV.
Timothy P. Sheahan,Amy C. Sims,Sarah R. Leist,Alexandra Schäfer,John J. Won,Ariane J. Brown,Stephanie A. Montgomery,Alison Hogg,Darius Babusis,Michael O'neil Hanrahan Clarke,Jamie E. Spahn,Bauer Laura Elizabeth,Scott P. Sellers,Danielle P. Porter,Joy Y. Feng,Tomas Cihlar,Robert Jordan,Mark R. Denison,Ralph S. Baric +18 more
TL;DR: Remdesivir (RDV) has superior anti-MERS activity in vitro and in vivo compared to combination therapy with lopinavir, ritonavir and interferon beta and reduces severe lung pathology.
Journal ArticleDOI
Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase
Ariane J. Brown,John J. Won,Rachel L. Graham,Kenneth H. Dinnon,Amy C. Sims,Joy Y. Feng,Tomas Cihlar,Mark R. Denison,Ralph S. Baric,Timothy P. Sheahan +9 more
TL;DR: The known breadth and antiviral activity of RDV is extended to include both contemporary human and highly divergent zoonotic CoV and potentially enhance the ability to fight future emerging CoV.
Journal ArticleDOI
Therapeutic treatment with an oral prodrug of the remdesivir parental nucleoside is protective against SARS-CoV-2 pathogenesis in mice
Alexandra Schäfer,David R. Martinez,John J. Won,Rita M. Meganck,Fernando R. Moreira,Ariane J. Brown,Kendra Gully,M. Zweigart,William S. Conrad,S. May,Stephanie Dong,Rao Kalla,Kwon Soo Chun,Venice Du Pont,Darius Babusis,Jennifer Tang,Eisuke Murakami,Raju Subramanian,K Barrett,Blake J. Bleier,Roy Bannister,Joy Y. Feng,John P. Bilello,Tomas Cihlar,Richard L. Mackman,Stephanie A. Montgomery,Ralph S. Baric,Timothy P. Sheahan +27 more
TL;DR: The in vitro antiviral activity and in vivo therapeutic efficacy of GS-621763, an orally bioavailable prodrug ofGS-441524, the parent nucleoside of remdesivir, which targets the highly conserved virus RNA-dependent RNA polymerase of SARS-CoV-2 are demonstrated.
Posted ContentDOI
Therapeutic efficacy of an oral nucleoside analog of remdesivir against SARS-CoV-2 pathogenesis in mice.
Alexandra Schäfer,David R. Martinez,John J. Won,Fernanado R Moreira,Ariane J. Brown,Kendra Gully,Rao Kalla,Kwon Soo Chun,Venice Du Pont,Darius Babusis,Jennifer Tang,Eisuke Murakami,Raju Subramanian,Kimberly T Barrett,Blake J. Bleier,Roy Bannister,Joy Y. Feng,John P. Bilello,Tomas Cihlar,Richard L. Mackman,Stephanie A. Montgomery,Ralph S. Baric,Timothy P. Sheahan +22 more
TL;DR: In this paper, GS-621763, an orally bioavailable prodrug of GS-441524, the parental nucleoside of remdesivir, which targets the highly conserved RNA-dependent RNA polymerase, was shown to significantly reduce viral load, lung pathology, and improved pulmonary function in COVID-19 mouse model.
Posted ContentDOI
Host genetic variation guides hepacivirus clearance, chronicity, and liver fibrosis in mice
Ariane J. Brown,John J. Won,Raphael Wolfisberg,Ulrik Fahnøe,Nicholas Catanzaro,Ande West,Fernando R. Moreira,Mariana Nogueira Batista,Martin T. Ferris,Colton Linnertz,Sarah R. Leist,Cameron Nguyen,Gabriela De la Cruz,Bentley R. Midkiff,Yongjuan Xia,Stephanie A. Montgomery,Eva Billerbeck,Jens Bukh,Troels K. H. Scheel,Charles M. Rice,Timothy P. Sheahan +20 more
TL;DR: The Collaborative Cross (CC) is a robust mouse genetics resource comprised of a panel of recombinant inbred strains, which model the complexity of the human genome and provide a system within which to understand diseases driven by complex allelic variation as mentioned in this paper .