J
John L. Farber
Researcher at Drexel University
Publications - 7
Citations - 488
John L. Farber is an academic researcher from Drexel University. The author has contributed to research in topics: Cell killing & Lipid peroxidation. The author has an hindex of 6, co-authored 7 publications receiving 485 citations.
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Journal ArticleDOI
Mechanisms of the killing of cultured hepatocytes by hydrogen peroxide
Raphael Rubin,John L. Farber +1 more
TL;DR: Mechanisms of H2O2-induced cell injury were explored in primary cultures of rat hepatocytes, finding that the first pathway is prevented by the antioxidants DPPD and promethazine and is very likely related to the peroxidation of membrane phospholipids.
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Lipid peroxidation increases the molecular order of microsomal membranes.
TL;DR: ESR spectroscopy is a sensitive method of detecting changes in membrane order accompanying peroxidation of membrane lipids, and 12-doxylstearic acid was the most sensitive to the changes in membranes organization caused byperoxidation.
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Oxygen-mediated cell injury in the killing of cultured hepatocytes by acetaminophen
TL;DR: It is demonstrated that the toxicity of acetaminophen can be dissociated from the covalent binding of its metabolites and support the conclusion that the hepatocytes were lethally injured by an oxidative stress accompanying the mixed function oxidase-dependent biotransformation of acetamine.
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Lysosomal origin of the ferric iron required for cell killing by hydrogen peroxide
TL;DR: The data suggest that a lysosomal pool is the source of the ferric iron necessary for the killing of hepatocytes by H2O2.
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Structural alterations of the inner mitochondrial membrane in ischemic liver cell injury
TL;DR: Electron spin resonance spectroscopy of mitoplasts spin labeled with either 5- or 12-doxyl stearic acid revealed an increased molecular order of ischemic inner mitochondrial membranes consistent with the increased cholesterol to phospholipid ratio.