J
John M. Brittingham
Researcher at Becton Dickinson
Publications - 8
Citations - 838
John M. Brittingham is an academic researcher from Becton Dickinson. The author has contributed to research in topics: Abrasion (mechanical) & Anthrax vaccines. The author has an hindex of 6, co-authored 7 publications receiving 808 citations. Previous affiliations of John M. Brittingham include Research Triangle Park.
Papers
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Journal ArticleDOI
Improved genetic immunization via micromechanical disruption of skin-barrier function and targeted epidermal delivery.
John A. Mikszta,Jason B. Alarcon,John M. Brittingham,Diane E. Sutter,Ronald J. Pettis,Noel G. Harvey +5 more
TL;DR: The results provide the first in vivo use of microfabricated devices to breach the skin barrier and deliver vaccines topically, suggesting significant clinical and practical advantages over existing technologies.
Journal ArticleDOI
Protective Immunization against Inhalational Anthrax: A Comparison of Minimally Invasive Delivery Platforms
John A. Mikszta,Vincent J. Sullivan,Cheryl H. Dean,Andrea M. Waterston,Jason B. Alarcon,John P. Dekker,John M. Brittingham,Juan Huang,C. Robin Hwang,Matthew S. Ferriter,Ge Jiang,Kevin D. Mar,Kamal U. Saikh,Bradley G. Stiles,Chad J. Roy,Robert G. Ulrich,Noel G. Harvey +16 more
TL;DR: It is demonstrated, for the first time, that cutaneous or nasal mucosal administration of rPA provides complete protection against inhalational anthrax in rabbits.
Journal ArticleDOI
Microneedle-based intradermal delivery of the anthrax recombinant protective antigen vaccine.
John A. Mikszta,John P. Dekker,Noel G. Harvey,Cheryl H. Dean,John M. Brittingham,Joanne Huang,Vincent J. Sullivan,Beverly Dyas,Chad J. Roy,Robert G. Ulrich +9 more
TL;DR: Overall, the results suggest rPA formulated with aluminum adjuvant and administered to the skin by a microneedle-based device is as efficacious as i.m. vaccination.
Patent
Topical delivery of vaccines
TL;DR: In this article, it has been discovered that delivery of substances such as nucleic acids, amino acids and amino acid derivatives simultaneously with abrasion of the skin enhances delivery and the biological response as compared to application of the substance to previously abraded skin.
Patent
Intra-dermal delivery of biologically active agents
Colleen M Nycz,Glenn P. Vonk,John M. Brittingham,Ronald J. Pettis,Alfred Harvey,Robert L. Campbell,John A. Mikszta,Diane E. Sutter +7 more
TL;DR: In this paper, an improved method for the delivery of biologically active agents to the intradermal compartment of a subject's skin is described. But this method is not suitable for the treatment of cancer.