J
John P. Dekker
Researcher at Research Triangle Park
Publications - 8
Citations - 372
John P. Dekker is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Genotoxicity & Anthrax vaccines. The author has an hindex of 7, co-authored 8 publications receiving 361 citations. Previous affiliations of John P. Dekker include Becton Dickinson.
Papers
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Journal ArticleDOI
Protective Immunization against Inhalational Anthrax: A Comparison of Minimally Invasive Delivery Platforms
John A. Mikszta,Vincent J. Sullivan,Cheryl H. Dean,Andrea M. Waterston,Jason B. Alarcon,John P. Dekker,John M. Brittingham,Juan Huang,C. Robin Hwang,Matthew S. Ferriter,Ge Jiang,Kevin D. Mar,Kamal U. Saikh,Bradley G. Stiles,Chad J. Roy,Robert G. Ulrich,Noel G. Harvey +16 more
TL;DR: It is demonstrated, for the first time, that cutaneous or nasal mucosal administration of rPA provides complete protection against inhalational anthrax in rabbits.
Journal ArticleDOI
Microneedle-based intradermal delivery of the anthrax recombinant protective antigen vaccine.
John A. Mikszta,John P. Dekker,Noel G. Harvey,Cheryl H. Dean,John M. Brittingham,Joanne Huang,Vincent J. Sullivan,Beverly Dyas,Chad J. Roy,Robert G. Ulrich +9 more
TL;DR: Overall, the results suggest rPA formulated with aluminum adjuvant and administered to the skin by a microneedle-based device is as efficacious as i.m. vaccination.
Patent
Method for delivering interferons to the intradermal compartment
TL;DR: In this article, the authors proposed methods and devices for intradermal delivery of substances, preferably therapeutic substances, by targeting the substance to the Intradermal compartment of a subject's skin.
Journal ArticleDOI
Effect of pentachlorophenol on the activation of 2,6-dinitrotoluene to genotoxic urinary metabolites in CD-1 mice: a comparison of GI enzyme activities and urine mutagenicity.
TL;DR: The enhanced genotoxicity observed in urines from 2,6‐DNT/PCP‐treated mice coincided with a decrease in nitroreductase and an increase in β‐glucuronidase activities in the small intestine, which led to a significant increase in mutagenicity.
Journal ArticleDOI
Potentiation of 2,6-dinitrotoluene genotoxicity in Fischer 344 rats by pretreatment with pentachlorophenol☆
R. W. Chadwick,S. Elizabeth George,Jerjang Chang,Michael J. Kohan,John P. Dekker,James E. Long,M.Catherine Duffy,Ronald Williams +7 more
TL;DR: This is the first report of a chemical interaction leading to increased DNA adduct formation and indicates that chemical interactions could be important to risk assessment since they alter the relationship between exposure, dose, and the effect of genotoxicants.