J
John McLauchlan
Researcher at University of Glasgow
Publications - 158
Citations - 9240
John McLauchlan is an academic researcher from University of Glasgow. The author has contributed to research in topics: Virus & Hepatitis C virus. The author has an hindex of 48, co-authored 148 publications receiving 8275 citations. Previous affiliations of John McLauchlan include Medical Research Council.
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Journal ArticleDOI
The consensus sequence YGTGTTYY located downstream from the AATAAA signal is required for efficient formation of mRNA 3′ termini
TL;DR: It is reported that a conserved sequence (consensus YGTGTTYY; Y = pyrimidine) located approximately 30bp downstream from the AATAAA signal is located downstream from 67% of the mammalian mRNA 3' termini examined.
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Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets
TL;DR: Evidence is provided that after cleavage by signal peptidase, the signal peptide is further processed by the intramembrane‐cleaving protease SPP that promotes the release of core protein from the ER membrane, then free for subsequent trafficking to lipid droplets.
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Impact of direct acting antiviral therapy in patients with chronic hepatitis C and decompensated cirrhosis.
Graham R. Foster,William L. Irving,Michelle Cheung,Alex J Walker,B Hudson,Suman Verma,John McLauchlan,David Mutimer,Ashley Brown,William Gelson,Douglas C. MacDonald,Kosh Agarwal +11 more
TL;DR: All oral DAAs effectively cured HCV in patients with advanced liver disease and Viral clearance was associated with improvement in liver function within 6months compared to untreated patients.
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Outcomes after successful direct-acting antiviral therapy for patients with chronic hepatitis C and decompensated cirrhosis
Michelle Cheung,Alex J Walker,B Hudson,Suman Verma,John McLauchlan,David Mutimer,Ashley Brown,William Gelson,Douglas C. MacDonald,Kosh Agarwal,Graham R. Foster,William L. Irving +11 more
TL;DR: It is suggested that antiviral therapy in patients with decompensated cirrhosis led to prolonged improvement in liver function, with no evidence of paradoxical adverse impact nor increase in liver malignancy.
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Properties of the hepatitis C virus core protein: a structural protein that modulates cellular processes
TL;DR: Key features of the polypeptide are described and the status of current knowledge on its ability to influence several cellular processes are described.