J
John R. Daum
Researcher at Oklahoma Medical Research Foundation
Publications - 30
Citations - 2377
John R. Daum is an academic researcher from Oklahoma Medical Research Foundation. The author has contributed to research in topics: Kinetochore & Mitosis. The author has an hindex of 18, co-authored 26 publications receiving 2183 citations. Previous affiliations of John R. Daum include University of Oklahoma Health Sciences Center & University of Virginia Health System.
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Journal ArticleDOI
Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis
Fangwei Wang,Jun Dai,John R. Daum,Ewa Niedzialkowska,Budhaditya Banerjee,P. Todd Stukenberg,Gary J. Gorbsky,Jonathan M.G. Higgins +7 more
TL;DR: It is shown that phosphorylation of histone H3 threonine 3 by Haspin is necessary for CPC accumulation at centromeres and that the CPC subunit Survivin binds directly to H3T3ph.
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The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity
Mark L. McCleland,Richard D. Gardner,Marko J. Kallio,John R. Daum,Gary J. Gorbsky,Daniel J. Burke,P. Todd Stukenberg +6 more
TL;DR: It is demonstrated that the spindle checkpoint can arrest budding yeast cells lacking NDC80 or Nuf2, whereas yeast lacking both proteins fail to arrest in mitosis, and proposed that the Ndc80 complex has conserved roles in kinetochore assembly, chromosome congression, and spindle checkpoints signaling.
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Mammalian p55CDC Mediates Association of the Spindle Checkpoint Protein Mad2 with the Cyclosome/Anaphase-promoting Complex, and is Involved in Regulating Anaphase Onset and Late Mitotic Events
TL;DR: Investigation of the function of p55CDC in Saccharomyces cerevisiae and Drosophila and extracts prepared from M phase, but not from interphase HeLa cells, suggest that mammalian p55 CDC may be part of a regulatory and targeting complex for the anaphase-promoting complex.
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The Reversibility of Mitotic Exit in Vertebrate Cells
Tamara A. Potapova,John R. Daum,Bradley D. Pittman,Joanna Hudson,Tara N. Jones,David L. Satinover,P. Todd Stukenberg,Gary J. Gorbsky +7 more
TL;DR: It is demonstrated that proteasome-dependent degradation of cyclin B provides directionality for the M phase to G1 transition for mitotic exit, which is regulated by degradation of the cyclin-dependent kinase 1 (Cdk1) activator, Cyclin B.
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Ska3 Is Required for Spindle Checkpoint Silencing and the Maintenance of Chromosome Cohesion in Mitosis
John R. Daum,Jonathan D. Wren,Jeremy J. Daniel,Sushama Sivakumar,Jennifer N. McAvoy,Tamara A. Potapova,Gary J. Gorbsky,Gary J. Gorbsky +7 more
TL;DR: It is suggested that this network plays a major role in silencing the spindle checkpoint when chromosomes are aligned at metaphase to allow timely anaphase onset and mitotic exit.