F
Fangwei Wang
Researcher at Life Sciences Institute
Publications - 62
Citations - 2439
Fangwei Wang is an academic researcher from Life Sciences Institute. The author has contributed to research in topics: Kinetochore & Centromere. The author has an hindex of 21, co-authored 55 publications receiving 1753 citations. Previous affiliations of Fangwei Wang include Zhejiang University & Brigham and Women's Hospital.
Papers
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Journal ArticleDOI
Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis
Fangwei Wang,Jun Dai,John R. Daum,Ewa Niedzialkowska,Budhaditya Banerjee,P. Todd Stukenberg,Gary J. Gorbsky,Jonathan M.G. Higgins +7 more
TL;DR: It is shown that phosphorylation of histone H3 threonine 3 by Haspin is necessary for CPC accumulation at centromeres and that the CPC subunit Survivin binds directly to H3T3ph.
Journal ArticleDOI
Histone modifications and mitosis: countermarks, landmarks, and bookmarks.
TL;DR: An integrated view of how histone modifications act as 'countermarks', 'landmarks', and 'bookmarks' to displace, recruit, and 'remember' the location of regulatory proteins during and shortly after mitosis is provided.
Journal ArticleDOI
A Positive Feedback Loop Involving Haspin and Aurora B Promotes CPC Accumulation at Centromeres in Mitosis
Fangwei Wang,Natalia P. Ulyanova,Maike S. van der Waal,Debasis Patnaik,Susanne M.A. Lens,Jonathan M.G. Higgins +5 more
TL;DR: It is proposed that Aurora B activity triggers a CPC-Haspin-H3T 3ph feedback loop that promotes generation of H3T3ph on chromatin, indicating an intimate linkage between Aurora B and Haspin functions in mitosis.
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Structure and Functional Characterization of the Atypical Human Kinase Haspin.
Jeyanthy Eswaran,Debasis Patnaik,Panagis Filippakopoulos,Fangwei Wang,Ross L. Stein,James W. Murray,Jonathan M.G. Higgins,Stefan Knapp +7 more
TL;DR: These structures reveal a constitutively active kinase conformation, stabilized by haspin-specific inserts, and a detailed analysis of histone modifications in the neighborhood of H3T3 reveals that increasing methylation at Lys-4 (H3K4) strongly decreases substrate recognition, suggesting a key role of H 3K4 methylation in the regulation of haspin activity.
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Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation
Fangwei Wang,Natalia P. Ulyanova,John R. Daum,Debasis Patnaik,Anna V. Kateneva,Gary J. Gorbsky,Jonathan M.G. Higgins +6 more
TL;DR: Haspin inhibitors reveal that Aurora B at centromeres is required for metaphase chromosome alignment and spindle checkpoint signaling.