J
John Roque
Researcher at University of Texas at Arlington
Publications - 24
Citations - 1167
John Roque is an academic researcher from University of Texas at Arlington. The author has contributed to research in topics: Photodynamic therapy & Photosensitizer. The author has an hindex of 10, co-authored 21 publications receiving 641 citations. Previous affiliations of John Roque include University of North Carolina at Greensboro & University of Rhode Island.
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Journal ArticleDOI
Transition Metal Complexes and Photodynamic Therapy from a Tumor-Centered Approach: Challenges, Opportunities, and Highlights from the Development of TLD1433
Susan Monro,Katsuya L. Colón,Huimin Yin,John Roque,Prathyusha Konda,Shashi Gujar,Randolph P. Thummel,Lothar Lilge,Colin G. Cameron,Sherri A. McFarland,Sherri A. McFarland +10 more
TL;DR: The challenges to bringing PDT into mainstream cancer therapy are summarized, the chemical and photophysical solutions that transition metal complexes offer are considered, and the multidisciplinary effort needed to bring a new drug to clinical trial is put into context.
Journal ArticleDOI
Near-infrared absorbing Ru(ii) complexes act as immunoprotective photodynamic therapy (PDT) agents against aggressive melanoma.
Liubov M. Lifshits,John Roque,John Roque,Prathyusha Konda,Susan Monro,Houston D. Cole,David von Dohlen,S.D. Kim,Gagan Deep,Randolph P. Thummel,Colin G. Cameron,Shashi Gujar,Sherri A. McFarland +12 more
TL;DR: Female and male mice vaccinated with B16F10 cells that were PDT-treated with 2 and challenged with live B16f10 cells exhibited 80 and 55% protection from tumor growth, respectively, leading to significantly improved survival and excellent hazard ratios of ≤0.2.
Journal ArticleDOI
Breaking the barrier: an osmium photosensitizer with unprecedented hypoxic phototoxicity for real world photodynamic therapy
John Roque,John Roque,Patrick C. Barrett,Houston D. Cole,Liubov M. Lifshits,Ge Shi,Susan Monro,David von Dohlen,S.D. Kim,Nino Russo,Gagan Deep,Colin G. Cameron,Colin G. Cameron,Marta E. Alberto,Sherri A. McFarland,Sherri A. McFarland,Sherri A. McFarland +16 more
TL;DR: In this article, the first metal-based photosensitizer was reported to have a phototherapeutic index (PI) exceeding 106 in normal and hypoxia conditions.
Journal ArticleDOI
A New Class of Homoleptic and Heteroleptic Bis(terpyridine) Iridium(III) Complexes with Strong Photodynamic Therapy Effects.
Bingqing Liu,Susan Monro,Zhike Li,Mohammed A. Jabed,Daniel Ramirez,Colin G. Cameron,Katsuya L. Colón,John Roque,Svetlana Kilina,Jian Tian,Sherri A. McFarland,Sherri A. McFarland,Wenfang Sun +12 more
TL;DR: A study on the transient absorption of these complexes demonstrated that they all possessed broadband triplet excited-state absorption in the 400-800 nm region, the largest reported for an Ir(III) complex photosensitizer upon broadband visible light (400-700 nm) activation.
Journal ArticleDOI
Strained, Photoejecting Ru(II) Complexes that are Cytotoxic Under Hypoxic Conditions
John Roque,Dmytro Havrylyuk,Patrick C. Barrett,Tariq Sainuddin,Julia McCain,Katsuya L. Colón,William T. Sparks,Evan Bradner,Susan Monro,David K. Heidary,Colin G. Cameron,Edith C. Glazer,Sherri A. McFarland,Sherri A. McFarland +13 more
TL;DR: The structure and nature of the aromatic group had a subtle impact on photochemistry, altering environmental sensitivity, and had a significant impact on cellular cytotoxicity and photobiology.