J
John S. Waye
Researcher at McMaster University
Publications - 195
Citations - 7836
John S. Waye is an academic researcher from McMaster University. The author has contributed to research in topics: Compound heterozygosity & Population. The author has an hindex of 41, co-authored 195 publications receiving 7529 citations. Previous affiliations of John S. Waye include Stanford University & McMaster University Medical Centre.
Papers
More filters
Journal ArticleDOI
Technical note: improved DNA extraction from ancient bones using silica-based spin columns
TL;DR: A simple method for extracting polymerase chain reaction-amplifiable DNA from ancient bones without the use of organic solvents is described.
Journal ArticleDOI
Gene for von Recklinghausen neurofibromatosis is in the pericentromeric region of chromosome 17
David F. Barker,E.C. Wright,K. Nguyen,L. A. Cannon,Pamela R. Fain,David E. Goldgar,D. T. Bishop,John C. Carey,Bonnie J. Baty,Jane D. Kivlin,Huntington F. Willard,John S. Waye,Gillian M. Greig,Leslie A. Leinwand,Yusuke Nakamura,Peter O'Connell,Mark Leppert,Jean-Marc Lalouel,Richard M. White,Mark H. Skolnick +19 more
TL;DR: Linkage analysis of 15 Utah kindreds demonstrated that a gene responsible for von Recklinghausen neurofibromatosis is located near the centromere on chromosome 17, indicating that a significant proportion of NF cases are due to mutations at a single locus.
Journal ArticleDOI
Hierarchical order in chromosome-specific human alpha satellite DNA
TL;DR: Analysis of the sequence organization of these diverged chromosomal subsets provides a framework for considering mechanisms of generation of sequence diversity and for understanding evolutionary processes of DNA family homogenization and polymorphism.
Journal ArticleDOI
Structure, organization, and sequence of alpha satellite DNA from human chromosome 17: evidence for evolution by unequal crossing-over and an ancestral pentamer repeat shared with the human X chromosome.
TL;DR: It is suggested that the chromosome 17 and X alpha satellite subsets may be related components of a larger alphoid subfamily which have evolved from a common ancestral repeat into the contemporary chromosome-specific subsets.
Journal ArticleDOI
Genomic organization of alpha satellite DNA on human chromosome 7: evidence for two distinct alphoid domains on a single chromosome.
TL;DR: Evidence is presented that there are at least two independent domains of alpha satellite DNA on chromosome 7, each characterized by their own distinct higher-order repeat structure, and mechanisms by which multiple unrelated higher- order repeat domains may be formed and maintained within a single chromosomal subset are proposed.