M
Mark H. Skolnick
Researcher at Myriad Genetics
Publications - 211
Citations - 31437
Mark H. Skolnick is an academic researcher from Myriad Genetics. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 64, co-authored 211 publications receiving 30548 citations. Previous affiliations of Mark H. Skolnick include International Agency for Research on Cancer & University of California, Berkeley.
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Journal ArticleDOI
A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
Yoshio Miki,Jeff Swensen,Donna M Shattuck-Eidens,P. Andrew Futreal,Keith D Harshman,Sean V. Tavtigian,Qingyun Liu,Charles Cochran,L. Michelle Bennett,Wei Ding,Russell Bell,Judith Rosenthal,Charles E. Hussey,Thanh Tran,Melody McClure,Cheryl Frye,Tom Hattier,Robert Phelps,Astrid Haugen-Strano,Harold Katcher,Kazuko Yakumo,Zahra Gholami,Daniel Shaffer,Steven Stone,Steven Bayer,Christian Wray,Robert Bogden,Priya Dayananth,John R. Ward,Patricia N. Tonin,Steven A. Narod,Pam K. Bristow,Frank H. Norris,Leah M. Helvering,Paul Morrison,Paul Robert Rosteck,Mei Lai,J. Carl Barrett,Cathryn M. Lewis,Susan L. Neuhausen,Lisa A. Cannon-Albright,David E. Goldgar,Roger W. Wiseman,Alexander Kamb,Mark H. Skolnick +44 more
TL;DR: A strong candidate for the 17q-linked BRCA1 gene, which influences susceptibility to breast and ovarian cancer, has been identified by positional cloning methods.
Journal ArticleDOI
A cell cycle regulator potentially involved in genesis of many tumor types
Alexander Kamb,Nelleke A. Gruis,Jane Weaver-Feldhaus,Qingyun Liu,Keith D Harshman,Sean V. Tavtigian,Elisabeth Stockert,Rufus S. Day,Bruce E. Johnson,Mark H. Skolnick,Mark H. Skolnick +10 more
TL;DR: Findings suggest that MTS1 mutations are involved in tumor formation in a wide range of tissues.
Journal ArticleDOI
Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13
Richard Wooster,Susan L. Neuhausen,Jonathan Mangion,Yvette Quirk,D Ford,N. Collins,K. Nguyen,Sheila Seal,T.D. Tran,D. Averill,P Fields,Gill Marshall,Steven A. Narod,Gilbert M. Lenoir,Henry T. Lynch,Jean Feunteun,Peter Devilee,Cees J. Cornelisse,Fred H. Menko,Peter A. Daly,Wilma Ormiston,Ross McManus,Carole Pye,Cathryn M. Lewis,Lisa A. Cannon-Albright,Julian Peto,Bruce A.J. Ponder,Mark H. Skolnick,Douglas F. Easton,David E. Goldgar,Michael R. Stratton +30 more
TL;DR: This analysis localized a second breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome 13q12-13, which preliminary evidence suggests suggests confers a high risk of breast cancer but does not confer a substantially elevated risk of ovarian cancer.
Journal ArticleDOI
The genome of the domesticated apple ( Malus × domestica Borkh.)
Riccardo Velasco,Andrey Zharkikh,Jason P. Affourtit,Amit Dhingra,Alessandro Cestaro,Ananth Kalyanaraman,Paolo Fontana,Satish Bhatnagar,Michela Troggio,Dmitry Pruss,Silvio Salvi,Massimo Pindo,Paolo Baldi,Sara Castelletti,Marina Cavaiuolo,G. Coppola,Fabrizio Costa,V. Cova,Antonio Dal Ri,Vadim V. Goremykin,M. Komjanc,Sara Longhi,P. Magnago,Giulia Malacarne,Mickael Malnoy,Diego Micheletti,Marco Moretto,Michele Perazzolli,Azeddine Si-Ammour,Silvia Vezzulli,E. Zini,Glenn Eldredge,Lisa M. Fitzgerald,N. Gutin,Jerry S. Lanchbury,Teresita Macalma,J.T. Mitchell,Julia Reid,Bryan Wardell,Chinnappa D. Kodira,Zhoutao Chen,Brian Desany,Faheem Niazi,Melinda Palmer,Tyson Koepke,Derick Jiwan,Scott Schaeffer,Vandhana Krishnan,Changjun Wu,Vu T. Chu,Stephen T. King,Jessica Vick,Quanzhou Tao,Amy Mraz,Aimee Stormo,Keith E. Stormo,Robert Bogden,Davide Ederle,Alessandra Stella,Alberto Vecchietti,Martin M. Kater,Simona Masiero,Pauline Lasserre,Yves Lespinasse,Andrew C. Allan,Vincent G. M. Bus,David Chagné,Ross N. Crowhurst,Andrew P. Gleave,Enrico Lavezzo,Jeffrey A. Fawcett,Jeffrey A. Fawcett,Sebastian Proost,Sebastian Proost,Pierre Rouzé,Pierre Rouzé,Lieven Sterck,Lieven Sterck,Stefano Toppo,Barbara Lazzari,Roger P. Hellens,Charles-Eric Durel,Alexander Gutin,Roger E. Bumgarner,Susan E. Gardiner,Mark H. Skolnick,Michael Egholm,Yves Van de Peer,Yves Van de Peer,Francesco Salamini,Roberto Viola +90 more
TL;DR: It is shown that a relatively recent (>50 million years ago) genome-wide duplication has resulted in the transition from nine ancestral chromosomes to 17 chromosomes in the Pyreae, which partly support the monophyly of the ancestral paleohexaploidy of eudicots.
Journal ArticleDOI
BRCA1 mutations in primary breast and ovarian carcinomas
P. Andrew Futreal,Qingyun Liu,Donna M Shattuck-Eidens,Charles Cochran,Keith D Harshman,Sean V. Tavtigian,L. Michelle Bennett,Astrid Haugen-Strano,Jeff Swensen,Yoshio Miki,Ken Eddington,Melody McClure,Cheryl Frye,Jane Weaver-Feldhaus,Wei Ding,Zahra Gholami,Peter Söderkvist,Lori A. Terry,Suresh C. Jhanwar,Andrew Berchuck,J. Dirk Iglehart,Jeffrey R. Marks,Dennis G. Ballinger,J. Cari Barrett,Mark H. Skolnick,Mark H. Skolnick,Alexander Kamb,Roger W. Wiseman +27 more
TL;DR: Results suggest that mutation of BRCA1 may not be critical in the development of the majority of breast and ovarian cancers that arise in the absence of a mutant germline allele.