John T. Fell

TL;DR: In this article, the availability of a poorly absorbed drug, hydrochlorothiazide, was determined from two formulations: a bioadhesive poly(acrylic acid) (Carbopol) formulation, which showed delayed transit to the ileocaecal junction, and a similar non-adhesive formulation.

TL;DR: Gamma scintigraphy was used to measure the gastric emptying rates of three test meals in human volunteers and it was shown that the emptying of solids from the stomach was significantly slower than that of liquid.

TL;DR: Intradermal dextran in ASH rats (doses between IOOpg and 1 mg) produced a dose-dependent increase in dye leakage, but again PS in doses up to 50pg failed to enhance these responses, and in NR rats, deXTran alone was 250 times weaker than inASH rats and PS was ineffective.

TL;DR: F-NMR has been used to assess the movement of a non-disintegrating pellet containing a fluorinated derivative of pentaerythritol in the gastrointestinal tract of a rat.

TL;DR: In this paper, a double compression technique was used to extract granules from glass ballotini by wet massing and screening, and three binders, polyvinylpyrollidone, hydroxypropylmethylcellulose and hydrolysed gelatin, were used and the resultant granules stored at two relative humidities.