J
John W. McDonald
Researcher at Johns Hopkins University School of Medicine
Publications - 93
Citations - 11834
John W. McDonald is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Spinal cord injury & NMDA receptor. The author has an hindex of 44, co-authored 91 publications receiving 11344 citations. Previous affiliations of John W. McDonald include Washington University in St. Louis & Kennedy Krieger Institute.
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Journal ArticleDOI
Spinal-cord injury
TL;DR: An overview of the newer therapeutic interventions employed in the care of the spinal cord injured individual and the theoretical rationale supporting them is presented.
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Physiological and pathophysiological roles of excitatory amino acids during central nervous system development
TL;DR: Potential therapeutic approaches may be rationally devised based on recent information about the developmental regulation of EAA receptors and their involvement in the pathogenesis of these disorders.
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Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord.
John W. McDonald,Xiao Zhong Liu,Yun Qu,Su Liu,Shannon K. Mickey,Dorothy M. Turetsky,David I. Gottlieb,Dennis W. Choi +7 more
TL;DR: Transplantation approaches using cellular bridges, fetal central nervous system cells, fibroblasts expressing neurotrophin-3, hybridoma cells expressing inhibitory protein-blocking antibodies, or olfactory nerves ensheathing glial cells transplanted into the acutely injured spinal cord have produced axonal regrowth or functional benefits.
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Neuronal and glial apoptosis after traumatic spinal cord injury.
Xiao Z. Liu,Xiao M. Xu,Rong Hu,Cheng Du,Shu X. Zhang,John W. McDonald,Hong X. Dong,Ying J. Wu,Guang S. Fan,Mark F. Jacquin,Chung Y. Hsu,Dennis W. Choi +11 more
TL;DR: The hypothesis that apoptosis dependent on active protein synthesis contributes to the neuronal and glial cell death, as well as to the neurological dysfunction, induced by mild-to-moderate severity traumatic insults to the rat spinal cord is supported.
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Embryonic stem cells differentiate into oligodendrocytes and myelinate in culture and after spinal cord transplantation
Su Liu,Yun Qu,Todd J. Stewart,Michael J. Howard,Shushovan Chakrabortty,Terrence F. Holekamp,John W. McDonald +6 more
TL;DR: The ability of ES cell-derived oligodendrocytes to myelinate axons in culture and to replace lost myelin in the injured adult CNS is demonstrated.