John Wright

TL;DR: Immunoelectron microscopic studies of an epitope in the extensible segment of titin revealed a transition in the elastic behavior of the titin filaments near the yield point sarcomere length of these muscles, providing direct evidence of tit in's involvement in the genesis of resting tension.

TL;DR: Immunoblot analysis indicates that although polypeptides of similar size are present in cardiac and smooth muscles at low abundance, those proteins show no immunological cross-reactivity with skeletal muscle nebulin, and raises the possibility that nebulin and titin might act as organizing templates and length-determining factors for actin and myosin respectively.

TL;DR: In this article, the authors investigated the structural role of the endosarcomeric lattices of a rabbit psoas muscle fiber with respect to the relative immunoelectron microscopy of the elastic titin filaments.

TL;DR: In this article, a micromachined sensor array was developed for the rapid characterization of multi-component mixtures in aqueous media, using an array composed of individually immobilized polystyrene-polyethylene glycol composite microspheres selectively arranged in micro-achined etch cavities localized o n silicon wafers.

TL;DR: It is proposed that nebulin acts as a length- regulating template that determines thin filament length by matching its large number of 40-nm repeating domains with an equal number of helical repeats of the actin filaments.