J
Jon Bordner
Researcher at Pfizer
Publications - 83
Citations - 1989
Jon Bordner is an academic researcher from Pfizer. The author has contributed to research in topics: Sorbinil & Aldose reductase inhibitor. The author has an hindex of 25, co-authored 83 publications receiving 1898 citations. Previous affiliations of Jon Bordner include Harvard University.
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Journal ArticleDOI
Synthesis, in vitro and in vivo activity of novel 9-deoxo-9a-AZA-9a-homoerythromycin A derivatives; a new class of macrolide antibiotics, the azalides.
G. Michael Bright,Arthur Adam Nagel,Jon Bordner,Desai Kishor A,Joseph DiBrino,Jolanta Nowakowska,Lawrence A. Vincent,Richard M. Watrous,Frank C. Sciavolino,Arthur R. English,James A. Retsema,M Anderson,Lori Brennan,Roberta J. Borovoy,Caroline R. Cimochowski,J A Faiella,Arthur E. Girard,Dennis Girard,Carol Herbert,Mary Manousos,Rachel J. Mason +20 more
TL;DR: The overall in vitro/in vivo performance of N-methyl, C- 4'' epimers 3a and 9; and C-4'' amine 11 identify these compounds as the most interesting erythromycin A-superior agents.
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(1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: a potent new neuroprotectant which blocks N-methyl-D-aspartate responses.
Bertrand L. Chenard,Jon Bordner,Butler Todd W,Leslie K. Chambers,M. A. Collins,De Costa Dl,M. F. Ducat,M. L. Dumont,Carol B. Fox,E. Edward Mena +9 more
TL;DR: 20 shows great promise as a neuroprotective agent and may lack the side effects of compounds currently in clinical trials, although it appears to lack the psychomotor stimulant effects of nonselective competitive and channel-blocking NMDA antagonists.
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Solid-state acid-base interactions in complexes of heterocyclic bases with dicarboxylic acids: crystallography, hydrogen bond analysis, and 15N NMR spectroscopy.
TL;DR: Insight is provided into the structural characteristics of complexes involving heterocyclic bases and carboxylic acids, and X-ray crystallography and 15N solid-state NMR are truly complementary in elucidating hydrogen bonding interactions and the degree of proton transfer of these complexes.
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X-ray crystallographic and NMR studies on the origins of high enantioselectivity in diels-alder reactions catalyzed by a chiral diazaaluminolidine
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Relative and Absolute Stereochemistry of Pyripyropene A, A Potent, Bioavailable Inhibitor of Acyl-CoA:Cholesterol Acyltransferase (ACAT)
Hiroshi Tomoda,Hiroyuki Nishida,Youngkook Kim,Rika Obata,Toshiaki Sunazuka,Satoshi Omura,Jon Bordner,Mark A. Guadliana,Peter G. Dormer,Amos B. Smith +9 more