J
Jonathan D. Leavenworth
Researcher at University of Alabama at Birmingham
Publications - 3
Citations - 37
Jonathan D. Leavenworth is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: FOXP3 & Immunoglobulin E. The author has an hindex of 1, co-authored 3 publications receiving 4 citations.
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Journal ArticleDOI
Remodeling of the tumor microenvironment via disrupting Blimp1+ effector Treg activity augments response to anti-PD-1 blockade.
Michael L. Dixon,Lin Luo,Lin Luo,Sadashib Ghosh,Jeffrey M. Grimes,Jonathan D. Leavenworth,Jianmei W. Leavenworth +6 more
TL;DR: In this article, the effect of Foxp3-specific ablation of Blimp1 in Treg cells resulted in impaired suppressive activity and a reprogramming into effector T-cells, which were largely restricted to the tumor-infiltrating Treg population.
Journal ArticleDOI
Dysregulated follicular regulatory T cells and antibody responses exacerbate experimental autoimmune encephalomyelitis.
Lin Luo,Lin Luo,Xianzhen Hu,Michael L. Dixon,Brandon J. Pope,Jonathan D. Leavenworth,Chander Raman,William Meador,Jianmei W. Leavenworth +8 more
TL;DR: In this paper, the authors compared the MOG-induced encephalomyelitis (EAE) in mice with a FoxP3-specific ablation of the transcription factor Blimp1 to control mice.
Journal ArticleDOI
Lineage Reprogramming of Effector Regulatory T Cells in Cancer
TL;DR: The functional and transcriptional plasticity of effector Tregs in tumors remain largely to be explored as discussed by the authors, however, a more effective approach should specifically target intratumoral Treg or subvert local Treg-mediated suppression.