W
William Meador
Researcher at University of Alabama at Birmingham
Publications - 15
Citations - 473
William Meador is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Axon & Acute disseminated encephalomyelitis. The author has an hindex of 7, co-authored 15 publications receiving 419 citations. Previous affiliations of William Meador include United States Department of Veterans Affairs & Emory University.
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Journal ArticleDOI
Electrical stimulation promotes peripheral axon regeneration by enhanced neuronal neurotrophin signaling.
TL;DR: Electrical stimulation produces a potent enhancement of the regeneration of axons in cut peripheral nerves, which is independent of neurotrophin production by cells in their surrounding environment but is dependent on stimulation of trkB and its ligands in the regenerating axons themselves.
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Axon regeneration in peripheral nerves is enhanced by proteoglycan degradation.
Mari L. Groves,Robert J. McKeon,Erica Werner,Mehul Nagarsheth,William Meador,Arthur W. English +5 more
TL;DR: It is believed that enzymatic removal of GAGs is especially effective in promoting the ability of regenerating axons to select their pathway in the distal stump (or nerve graft) and, in the case of chondroitinase ABC or heparinase I, it may also promote growth within that pathway.
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Neurotrophin-4/5 is required for the early growth of regenerating axons in peripheral nerves.
TL;DR: In this paper, the axon profiles of YFP + axons measured in these grafts were compared with those measured in grafts obtained from wild-type donors, and axon profile lengths measured in the grafts from homozygous (NT-4/5 - / - ) or heterozygous(NT.4.5 +/ - ) mice were significantly shorter.
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Prevalence and characteristics of tremor in the NARCOMS multiple sclerosis registry: a cross-sectional survey.
John R. Rinker,John R. Rinker,Amber Salter,Harrison C. Walker,Amy W. Amara,William Meador,Gary Cutter +6 more
TL;DR: Tremor is common among NARCOMS registrants and severely disabling for some, and both ADL-based and symptom-descriptive measures of tremor severity can be used to stratify patients.
Journal ArticleDOI
Symptomatic Management of Multiple Sclerosis-Associated Tremor Among Participants in the NARCOMS Registry.
TL;DR: Patients with moderate-to-severe tremor are more likely to report tremor benefit than are those with mild or disabling tremor, and γ-Aminobutyric acid-active medications were most commonly reported as beneficial.