L
Lin Luo
Researcher at Nantong University
Publications - 15
Citations - 155
Lin Luo is an academic researcher from Nantong University. The author has contributed to research in topics: Immune system & FOXP3. The author has an hindex of 6, co-authored 13 publications receiving 79 citations. Previous affiliations of Lin Luo include University of Alabama at Birmingham & Sichuan University.
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Journal ArticleDOI
Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor
Erxia Shen,Erxia Shen,Hardis Rabe,Hardis Rabe,Lin Luo,Lin Luo,Lei Wang,Qin Wang,Qin Wang,Jie Yin,Jie Yin,Xueying Yang,Wenquan Liu,Wenquan Liu,Jessica M. Sido,Hidetoshi Nakagawa,Lin Ao,Hye-Jung Kim,Harvey Cantor,Jianmei W. Leavenworth +19 more
TL;DR: A Blimp1-dependent TFR checkpoint is uncovered that enforces suppressive activity and acts as a gatekeeper of GC entry and expression of regulatory activity.
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Rosuvastatin improves myocardial hypertrophy after hemodynamic pressure overload via regulating the crosstalk of Nrf2/ARE and TGF-β/ smads pathways in rat heart.
TL;DR: Results revealed the crosstalk between TGF‐&bgr;1/Smads and Nrf2/ antioxidant response elements (ARE) pathways in myocardial remodeling through the interaction between Smad7 and NRF2.
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Remodeling of the tumor microenvironment via disrupting Blimp1+ effector Treg activity augments response to anti-PD-1 blockade.
Michael L. Dixon,Lin Luo,Lin Luo,Sadashib Ghosh,Jeffrey M. Grimes,Jonathan D. Leavenworth,Jianmei W. Leavenworth +6 more
TL;DR: In this article, the effect of Foxp3-specific ablation of Blimp1 in Treg cells resulted in impaired suppressive activity and a reprogramming into effector T-cells, which were largely restricted to the tumor-infiltrating Treg population.
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A novel harmine derivative, N-(4-(hydroxycarbamoyl)benzyl)-1-(4- methoxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxamide (HBC), as histone deacetylase inhibitor: in vitro antiproliferation, apoptosis induction, cell cycle arrest, and antimetastatic effects.
Jiefei Miao,Yanfu Peng,Shi Chen,Weijie Gao,Yang Qiuxing,Peng Zhu,Jing Guo,Jinhua Tao,Lin Luo,Yanan Zhang,Yong Ling,Yong Ling +11 more
TL;DR: Novel harmine‐based HDAC inhibitor HBC not only exhibited selective HDAC1/6 inhibitory activity and significant in vitro and in vivo antitumor activity, but also possessed DNA binding effect, apoptosis induction, cell cycle arrest effects, and potent anti‐metastasis mechanisms, which may hold great promise as therapeutic agent targeting HDAC 1/6 for the intervention of human cancers.
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bFGF overexpression adipose derived mesenchymal stem cells improved the survival of pulmonary arterial endothelial cells via PI3k/Akt signaling pathway.
TL;DR: In this article, bFGF transfected mesenchymal stem cells (ASCs) improved the survival of human pulmonary arterial endothelial cells (HPAECs) by activating the PI3k/Akt pathway.